Vigora: Clinically Proven Treatment for Erectile Dysfunction
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Vigora is a prescription medication containing sildenafil citrate, a potent phosphodiesterase type 5 (PDE5) inhibitor, developed for the effective management of erectile dysfunction (ED). It functions by enhancing blood flow to the penile tissues, facilitating the achievement and maintenance of an erection sufficient for satisfactory sexual activity. This medication is intended for use under professional medical supervision, following a comprehensive evaluation of the patient’s cardiovascular health and overall suitability. Vigora represents a reliable therapeutic option backed by extensive clinical research and real-world efficacy data.
Features
- Active ingredient: Sildenafil citrate 100 mg
- Mechanism: Selective inhibition of phosphodiesterase type 5 (PDE5)
- Onset of action: Typically within 30–60 minutes post-administration
- Duration of effect: Up to 4–6 hours
- Formulation: Film-coated tablet for oral use
- Bioavailability: Approximately 40%
- Metabolism: Hepatic, primarily via CYP3A4 and CYP2C9 isoenzymes
- Excretion: Predominantly fecal (approx. 80%) and renal (approx. 13%)
Benefits
- Facilitates improved erectile function by increasing nitric oxide-mediated vasodilation in the corpus cavernosum
- Enhances sexual confidence and reduces anxiety associated with performance
- Supports spontaneous sexual activity due to a flexible dosing window
- Contributes to improved relationship satisfaction and quality of life
- Backed by over two decades of clinical safety and efficacy data
- Cost-effective alternative within the PDE5 inhibitor class
Common use
Vigora is primarily indicated for the treatment of erectile dysfunction in adult males. It is suitable for patients with various etiologies of ED, including vasculogenic, neurogenic, and psychogenic origins. It may be used in patients with stable cardiovascular disease, following appropriate risk assessment. It is not indicated for use in women, children, or adolescents.
Dosage and direction
The recommended starting dose for most patients is 50 mg, taken approximately one hour before anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. Dosage adjustment is necessary in patients aged over 65, those with hepatic impairment (Child-Pugh classes A and B), severe renal impairment (creatinine clearance <30 mL/min), and those taking concomitant CYP3A4 inhibitors. The maximum recommended dosing frequency is once per 24-hour period. Tablets should be swallowed whole with a glass of water; administration with a high-fat meal may delay absorption.
Precautions
Prior to initiating therapy, a thorough medical history and physical examination should be conducted to assess cardiovascular status, as sexual activity carries potential cardiac risk. Use with caution in patients with anatomical deformation of the penis (e.g., Peyronie’s disease), conditions predisposing to priapism (e.g., sickle cell anemia, multiple myeloma), bleeding disorders, or active peptic ulceration. Avoid excessive alcohol consumption (may increase risk of orthostatic hypotension). Not intended for use with other erectile dysfunction treatments. Protect tablets from moisture and light before use.
Contraindications
Vigora is contraindicated in patients with a known hypersensitivity to sildenafil or any excipients in the formulation. Concurrent use with organic nitrates or nitric oxide donors (e.g., amyl nitrite) in any form is strictly prohibited due to the risk of profound hypotension. It is also contraindicated in patients with severe hepatic impairment, hypotension (BP <90/50 mmHg), recent stroke or myocardial infarction, unstable angina, or hereditary degenerative retinal disorders.
Possible side effects
Common adverse reactions (≥1/100 to <1/10) include headache, flushing, dyspepsia, nasal congestion, and dizziness. Less frequently (≥1/1,000 to <1/100), visual disturbances (e.g., color tinge, blurred vision), palpitations, and nausea may occur. Rare but serious side effects include priapism (prolonged erection >4 hours), sudden hearing loss, non-arteritic anterior ischemic optic neuropathy (NAION), and cardiovascular events. Patients should seek immediate medical attention if an erection persists beyond 4 hours.
Drug interaction
Concomitant use with nitrates is absolutely contraindicated. Potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin) increase sildenafil plasma concentrations—dose reduction to 25 mg is recommended. Alpha-blockers (e.g., doxazosin) may potentiate hypotensive effects; separate administration by at least 4 hours. Grapefruit juice may increase bioavailability. Use with other antihypertensives may additive hypotensive effects. Caution advised with CYP3A4 inducers (e.g., rifampin), which may reduce efficacy.
Missed dose
Vigora is taken on an as-needed basis; there is no scheduled dosing regimen. If a dose is missed, it may be taken when remembered, provided the next dose is not scheduled within 24 hours. Do not double the dose to make up for a missed administration.
Overdose
In cases of overdose, standard supportive measures should be employed. Expected effects may include severe hypotension, syncope, and prolonged erection. Priapism requires urgent urological intervention to prevent permanent tissue damage. Hemodialysis is not expected to significantly enhance elimination due to high protein binding and extensive tissue distribution.
Storage
Store below 30°C (86°F) in the original packaging to protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment decisions, and individualized dosing recommendations. Do not initiate or discontinue medication without medical supervision.
Reviews
Clinical studies demonstrate that Vigora (sildenafil 100 mg) significantly improves erectile function in 82% of patients versus 24% on placebo (Goldstein et al., 1998). Real-world evidence supports high patient satisfaction and improved intercourse success rates. Common feedback highlights effective onset and duration, though some users report side effects like headache or flushing, typically mild and transient. Long-term users appreciate consistency and reliability when used as directed.