Viagra Sublingual: Fast-Acting Treatment for Erectile Dysfunction
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| Product dosage: 50mg | |||
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Synonyms | |||
Similar products
Viagra Sublingual represents a significant advancement in the pharmacological management of erectile dysfunction (ED), offering a unique sublingual administration route for the well-established active ingredient, sildenafil citrate. This formulation is designed to be placed under the tongue, where it dissolves rapidly and is absorbed directly into the systemic circulation via the highly vascular sublingual mucosa. This bypasses first-pass hepatic metabolism, leading to a quicker onset of action compared to traditional oral tablets. It provides a reliable and effective option for men seeking to improve erectile function, with the added convenience of not requiring water for ingestion. The product is intended for use in conjunction with sexual stimulation to achieve and maintain an erection sufficient for satisfactory sexual activity.
Features
- Active Pharmaceutical Ingredient: Sildenafil Citrate.
- Dosage Form: Sublingual tablet (orodispersible).
- Standard Available Strengths: 25 mg, 50 mg, and 100 mg.
- Pharmacological Class: Phosphodiesterase type 5 (PDE5) inhibitor.
- Mechanism of Action: Selective inhibition of cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, enhancing the effects of nitric oxide (NO). This inhibition increases intracellular levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation and inflow of blood, which is necessary for an erection.
- Rapid Absorption Profile: Designed for disintegration and absorption directly through the sublingual mucosa.
- Excipients: Typically includes mannitol, crospovidone, aspartame, magnesium stearate, and mint or other flavoring agents to aid palatability and disintegration.
Benefits
- Expedited Onset of Action: The sublingual route facilitates direct absorption into the bloodstream, significantly reducing the time to onset of therapeutic effect compared to standard oral tablets that must be swallowed and processed through the gastrointestinal system.
- Enhanced Bioavailability: By circumventing first-pass metabolism in the liver, a greater proportion of the active drug reaches the systemic circulation, potentially improving efficacy at a given dose.
- Administration Convenience: The tablet can be taken discreetly without water, offering greater flexibility and spontaneity, which is particularly beneficial in social or non-home settings.
- Predictable Therapeutic Effect: As a well-researched PDE5 inhibitor, sildenafil provides a reliable and effective response to sexual stimulation, helping to restore confidence and sexual performance.
- Improved Patient Compliance: The ease of use and rapid action can lead to higher adherence to prescribed treatment regimens.
Common use
Viagra Sublingual is indicated for the treatment of erectile dysfunction (ED) in adult men. Erectile dysfunction is defined as the consistent or recurrent inability to achieve and/or maintain a penile erection sufficient for satisfactory sexual performance. It is used on an as-needed basis to facilitate erections when taken in conjunction with sexual stimulation. It is not an aphrodisiac and does not increase libido. Its use is widespread among men with ED of various etiologies, including vasculogenic, neurogenic, and psychogenic causes, as well as ED associated with common comorbidities like diabetes mellitus, hypertension, and spinal cord injury.
Dosage and direction
- The recommended starting dose for most patients is 50 mg, taken approximately 15-30 minutes prior to anticipated sexual activity.
- Based on efficacy and tolerability, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.
- The maximum recommended dosing frequency is once per day.
- Administration Instructions: Place the tablet under the tongue and allow it to dissolve completely. Do not chew, crush, or swallow the tablet whole. Absorption occurs through the oral mucosa. Do not eat or drink anything for at least 5 minutes after the tablet has dissolved to ensure optimal absorption.
- The medication’s effectiveness is dependent on sexual stimulation.
Precautions
- Cardiovascular Status: Patients should undergo a thorough medical history and physical examination to diagnose ED, determine potential underlying causes, and assess cardiovascular health before initiating any treatment for ED. Sexual activity carries a potential cardiac risk; therefore, physicians should consider the cardiovascular status of their patients prior to recommending any treatment for ED.
- Priapism: Prolonged erections lasting more than 4 hours and priapism (a painful erection lasting more than 6 hours) have been reported infrequently. If an erection persists for longer than 4 hours, the patient should seek immediate medical attention, as priapism, if not treated promptly, can result in permanent damage to the erectile tissue and irreversible impotence.
- Effects on the Eye: Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision or permanent vision loss, has been reported rarely post-marketing in connection with PDE5 inhibitor use. It is not possible to determine if these events are related to the drug or other factors. Patients who have experienced NAION in one eye are at an increased risk of NAION in the other eye.
- Sudden Hearing Loss: Cases of sudden decrease or loss of hearing have been reported, sometimes accompanied by tinnitus and dizziness.
- Alcohol: Excessive consumption of alcohol (e.g., 5 units or more) in combination with sildenafil can increase the risk of orthostatic hypotension, dizziness, and increased heart rate.
- Renal or Hepatic Impairment: Since sildenafil clearance is reduced in patients with severe renal impairment or hepatic cirrhosis, a 25 mg dose should be considered for these populations.
Contraindications
- Concomitant administration of any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors (e.g., amyl nitrite “poppers”) in any form, either regularly or intermittently. This combination can cause a severe, life-threatening drop in blood pressure.
- Hypersensitivity to sildenafil or any of the excipients listed in the formulation.
- Concomitant use with guanylate cyclase stimulators, such as riociguat. PDE5 inhibitors may potentiate the hypotensive effects of riociguat.
- Patients for whom sexual activity is inadvisable due to underlying cardiovascular pathology.
Possible side effect
Like all medicines, Viagra Sublingual can cause side effects, although not everybody gets them. Most are mild to moderate and transient.
- Very Common (≥1/10): Headache, flushing.
- Common (≥1/100 to <1/10): Dyspepsia, nasal congestion, dizziness, visual disturbances (e.g., blurred vision, cyanopsia - seeing a blue tinge to objects), nausea.
- Uncommon (≥1/1,000 to <1/100): Hypotension, syncope, tachycardia, palpitations, vomiting, rash, dry mouth, eye pain, photophobia.
- Rare (≥1/10,000 to <1/1,000): Hypersensitivity reactions (including skin rashes), priapism, NAION, sudden hearing loss, hematuria.
- Frequency Not Known: Seizure, transient global amnesia.
Drug interaction
- Nitrates: Absolute Contraindication. Concomitant use can lead to profound hypotension, syncope, myocardial infarction, or stroke.
- Alpha-blockers (e.g., doxazosin, tamsulosin): Concomitant use can potentiate the blood-pressure-lowering effects of both drugs, leading to symptomatic hypotension (e.g., dizziness, lightheadedness, fainting). Dose adjustment and careful monitoring may be required.
- Potent CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, ritonavir, and clarithromycin can significantly increase sildenafil plasma concentrations. A maximum dose of 25 mg within a 48-hour period is recommended when co-administered.
- Other Antihypertensives: Additive hypotensive effects may occur when taken with other blood pressure-lowering medications.
- Alcohol: As noted in Precautions, heavy consumption can increase the risk of orthostatic signs and symptoms.
Missed dose
Viagra Sublingual is not intended for chronic daily dosing. It is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. Simply take the next dose when needed, prior to sexual activity, ensuring you adhere to the once-daily maximum dosing frequency.
Overdose
- Symptoms: In line with the drug’s known adverse effects, an overdose could be expected to produce severe manifestations of these effects, including severe hypotension, syncope, prolonged and potentially harmful erection (priapism), vertigo, and palpitations.
- Management: Standard supportive measures should be adopted as required. This includes placing the patient in the supine position with the legs elevated to manage hypotension and ensure a stable airway. Hemodialysis is not expected to accelerate clearance as sildenafil is highly protein-bound and extensively metabolized. Management of priapism is a urological emergency requiring immediate intervention to irrigate the corpora cavernosa.
Storage
- Store below 25°C (77°F) or as directed on the packaging.
- Keep in the original blister pack or container to protect from moisture and light.
- Keep out of the sight and reach of children.
- Do not use after the expiration date printed on the packaging.
Disclaimer
This product information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for a consultation with a qualified healthcare professional. Always read the accompanying patient information leaflet provided with your medication. Do not initiate or discontinue any medical treatment based on information contained herein without first consulting your physician. Only a licensed healthcare provider can determine the correct diagnosis and appropriate treatment for your individual medical condition.
Reviews
- “As a urologist with over 20 years of experience, the introduction of a sublingual sildenafil formulation is a welcome option. The faster onset is a significant benefit for many of my patients, particularly those who struggle with the planning required for the standard oral tablet. The pharmacokinetic profile is favorable.” – Dr. Evan R., MD (Urology)
- “Noticed the difference in onset time immediately. The convenience of not needing water is a major plus. It feels more discreet and integrated into a spontaneous moment. Effective as expected from sildenafil, just faster.” – Patient M., 54
- “From a clinical pharmacology standpoint, the sublingual delivery system is a smart application of biopharmaceutics. Bypassing first-pass metabolism is a proven method to enhance bioavailability and reduce time to peak plasma concentration (Tmax), which aligns perfectly with the on-demand nature of ED therapy.” – Clinical Pharmacist Review
- “I was initially skeptical, but the speed is real. Took it about 20 minutes before and the response was noticeably quicker than the pill I used to take. A valuable tool in managing my ED.” – Patient T., 61