Tretinoin 0.05% Cream: Advanced Topical Retinoid for Skin Renewal
| Product dosage: 20g | |||
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Tretinoin 0.05% is a prescription-strength topical retinoid formulation clinically proven to address multiple dermatologic concerns through targeted cellular activity. As a derivative of vitamin A, it functions by binding to specific nuclear receptors in the skin, modulating cellular differentiation and proliferation. This mechanism promotes accelerated epidermal turnover, facilitates the expulsion of comedones, and stimulates collagen synthesis. The 0.05% concentration represents an intermediate potency option, balancing efficacy with tolerability for sustained therapeutic use under dermatological supervision.
Features
- Contains 0.05% tretinoin in a micronized formulation for enhanced stability and penetration
- Available in cream base optimized for normal to dry skin types
- pH-balanced formulation (5.5-6.0) to maintain skin barrier integrity
- Non-comedogenic, fragrance-free, and alcohol-free vehicle
- Stabilized with antioxidants to prevent oxidative degradation
- Manufactured under cGMP standards with batch-to-batch consistency
Benefits
- Significantly reduces the appearance of fine lines and wrinkles through collagen neosynthesis
- Diminishes hyperpigmentation and evens skin tone by inhibiting melanin transfer
- Unclogs pores and prevents microcomedone formation, reducing acne lesions
- Improves skin texture and elasticity through epidermal remodeling
- Enhances penetration and efficacy of complementary topical agents
- Provides cumulative, long-term improvements in photoaged skin quality
Common use
Tretinoin 0.05% cream is primarily indicated for the treatment of acne vulgaris, particularly comedonal and inflammatory acne, where it helps prevent the formation of new lesions and reduces existing ones. It is equally valuable in addressing photodamage, including fine wrinkles, mottled hyperpigmentation, and rough skin texture resulting from chronic sun exposure. Off-label applications include management of keratosis pilaris, striae distensae, and certain forms of ichthyosis. The product demonstrates particular efficacy in cases where lower concentrations have proven insufficient or where patients have developed tolerance to initial therapies.
Dosage and direction
Apply a pea-sized amount of tretinoin 0.05% cream to the entire affected area once daily, preferably in the evening. Begin with application every second or third night for the first 2-3 weeks to allow cutaneous adaptation, gradually increasing to nightly use as tolerated. Cleanse the skin with a mild, non-medicated cleanser and pat dry thoroughly before application. Wait 20-30 minutes after washing to ensure complete skin dryness, as application to damp skin may increase irritation. Dot small amounts evenly across the forehead, cheeks, chin, and nose, then gently smooth into a thin layer avoiding the eye area, lips, and mucous membranes. Morning application should include broad-spectrum sunscreen with SPF 30 or higher.
Precautions
Tretinoin increases photosensitivity, necessitating strict sun protection including protective clothing and avoidance of excessive sun exposure. Initial therapy may cause redness, peeling, and dryness (retinization period) which typically subsides within 2-6 weeks of continued use. Avoid concomitant use of other potentially irritating products including astringents, abrasives, high-concentration alpha hydroxy acids, or benzoyl peroxide unless specifically directed by a dermatologist. Do not apply to eczematous, sunburned, or broken skin. Exercise caution when using around the nasal labial folds and neck where skin is more sensitive. Contact with eyes, mouth, and angles of the nose should be avoided. Weather extremes, particularly windy or cold conditions, may exacerbate skin irritation during treatment.
Contraindications
This product is contraindicated in individuals with known hypersensitivity to tretinoin or any component of the formulation. Should not be used during pregnancy (Category C) or by women who are breastfeeding due to potential systemic absorption and teratogenic risk. Not recommended for patients with personal or family history of cutaneous lupus erythematosus or porphyria. Avoid use in patients with severe cystic acne, rosacea, or seborrheic dermatitis without medical supervision. Contraindicated in patients undergoing recent cryotherapy, chemical peeling, or laser resurfacing procedures until complete healing has occurred.
Possible side effects
Common expected effects include transient erythema, warmth, stinging, peeling, and dryness especially during the initial weeks of treatment. These typically diminish with continued use as the skin adapts. Less frequently, patients may experience photosensitivity reactions, blistering, crusting, or excessive irritation. Hyperpigmentation or hypopigmentation may occur, particularly in patients with darker skin types. Rare adverse effects include contact dermatitis, skin atrophy with prolonged use, and paradoxical acne flare. Systemic effects are uncommon with appropriate topical application but may include headache and increased serum triglycerides in cases of excessive use over large body surface areas.
Drug interaction
Concomitant use with other topical acne medications (benzoyl peroxide, salicylic acid) may increase irritation potential—space applications by several hours. Photosensitizing agents including tetracyclines, fluoroquinolones, sulfonamides, phenothiazines, and thiazides may compound photosensitivity risk. Topical corticosteroids may alter the therapeutic response to tretinoin. Avoid simultaneous use with other retinoids (oral or topical) due to potential additive effects. Mineral oil-based products may impede tretinoin absorption and efficacy. Caution advised with topical antibiotics as formulation compatibility may vary.
Missed dose
Apply the missed dose as soon as remembered, unless it is nearly time for the next application. Do not double the dose to make up for a missed application. If skipping a dose helps manage irritation, resume regular application schedule with the next dose. Consistent application is important for optimal results, but occasional missed doses are unlikely to significantly impact long-term efficacy. If multiple doses are missed, consider reinitiating therapy with reduced frequency to reacclimatize the skin.
Overdose
Topical overdose may manifest as severe erythema, peeling, burning, stinging, or edema. In case of excessive application, gently cleanse the area with mild soap and water to remove residual product. Apply cool compresses and bland emollients to soothe irritation. Systemic overdose through topical application is unlikely but could theoretically cause symptoms similar to hypervitaminosis A including headache, dizziness, and cheilitis. Supportive care should be provided based on symptoms. Medical attention is recommended if severe local reactions occur or if accidental ingestion happens.
Storage
Store at controlled room temperature (20-25°C or 68-77°F) in the original container with tightly closed lid. Protect from light and excessive heat as degradation occurs above 40°C (104°F). Do not freeze. Keep tube upright to prevent leakage. Discard any product that has changed color, consistency, or odor. Keep out of reach of children and pets. The product remains stable for 24 months from manufacturing date when stored properly. Do not transfer to other containers.
Disclaimer
This information does not replace professional medical advice. Consult a qualified healthcare provider for diagnosis and appropriate treatment options. Individual results may vary based on skin type, condition severity, and adherence to treatment protocol. The product should be used only as directed by a prescribing physician. Manufacturer is not liable for misuse or incorrect application. Full prescribing information available upon request from licensed healthcare professionals.
Reviews
Clinical studies demonstrate 60-75% improvement in acne lesions after 12 weeks of use with tretinoin 0.05% cream. In photoaging studies, significant improvement in fine wrinkles and hyperpigmentation observed in 80% of patients after 24 weeks. Dermatologist surveys indicate preference for this concentration as balance between efficacy and tolerability. Patient-reported satisfaction scores show high rates of improvement in skin texture and clarity. Long-term studies confirm maintenance of results with continued use and established safety profile up to 48 weeks of continuous application.