Trandate: Advanced Dual-Action Blood Pressure Control
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.91 | $57.23 (0%) | 🛒 Add to cart |
| 60 | $1.44 | $114.46 $86.35 (25%) | 🛒 Add to cart |
| 90 | $1.28 | $171.69 $115.47 (33%) | 🛒 Add to cart |
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| 270 | $1.07
Best per pill | $515.08 $290.17 (44%) | 🛒 Add to cart |
Synonyms | |||
Trandate (labetalol hydrochloride) is a prescription medication specifically formulated for the management of hypertension. As a combined alpha- and beta-adrenergic blocking agent, it offers a unique dual mechanism of action, making it a versatile choice in cardiovascular therapeutics. This agent is particularly valued in clinical settings for its efficacy in reducing blood pressure without significantly affecting heart rate, renal blood flow, or glomerular filtration rate in most patients. Its balanced pharmacological profile supports both outpatient chronic management and acute hypertensive scenarios under medical supervision.
Features
- Active ingredient: Labetalol hydrochloride
- Available in tablet and injectable formulations
- Dual alpha- and beta-adrenergic blocking properties
- Onset of action: Oral—within 2 hours; IV—within 5 minutes
- Half-life: Approximately 6–8 hours
- Metabolism: Primarily hepatic
- Excretion: Urinary and fecal
Benefits
- Effectively lowers both systolic and diastolic blood pressure through dual receptor blockade.
- Minimizes reflex tachycardia commonly associated with pure vasodilators.
- Suitable for a wide range of hypertensive patients, including those with comorbid conditions.
- Provides rapid blood pressure control in hypertensive emergencies when administered intravenously.
- Maintains renal perfusion, making it a favorable option in patients with renal impairment.
- Offers flexible dosing for individualized treatment plans.
Common use
Trandate is primarily indicated for the management of hypertension, either as monotherapy or in combination with other antihypertensive agents. It is also used in the treatment of hypertensive emergencies, pheochromocytoma (preoperatively and intraoperatively), and clonidine withdrawal hypertension. Off-label uses may include management of aortic dissection and certain cases of preeclampsia, though these require careful specialist oversight.
Dosage and direction
Oral administration (tablets):
- Initial dose: 100 mg twice daily, may be increased gradually every 2–3 days.
- Maintenance dose: 200–400 mg twice daily; maximum 2400 mg per day in divided doses.
- Should be taken consistently with or without food.
Intravenous administration:
- Reserved for hypertensive emergencies under clinical monitoring.
- Initial IV dose: 20 mg slow injection over 2 minutes.
- Subsequent doses: 40–80 mg at 10-minute intervals, up to 300 mg total.
- Continuous infusion may be administered at 2 mg/min, titrated to response.
Dosage adjustments are necessary in elderly patients, those with hepatic impairment, or during concomitant use of cimetidine.
Precautions
- Use with caution in patients with asthma, COPD, or other bronchospastic conditions.
- Monitor for signs of hepatic injury; discontinue if laboratory signs of hepatocellular damage occur.
- May mask tachycardia in hypoglycemia—use carefully in diabetics.
- Avoid abrupt withdrawal; taper over 1–2 weeks to prevent rebound hypertension.
- Orthostatic hypotension may occur—advise patients to rise slowly from sitting/lying positions.
- Not recommended during pregnancy unless potential benefit justifies potential risk.
Contraindications
- Bronchial asthma
- Overt cardiac failure
- Cardiogenic shock
- Severe bradycardia
- Second- or third-degree heart block
- Hypersensitivity to labetalol or any component of the formulation
Possible side effect
Common:
- Fatigue, dizziness, nausea
- Scalp tingling, nasal congestion
- Postural hypotension
Less common:
- Bronchospasm, dyspnea
- Edema, rash
- Vivid dreams, depression
Rare but serious:
- Hepatotoxicity, severe bradycardia
- Heart failure exacerbation
- Lupus-like syndrome
Drug interaction
- Potentiates hypotensive effects with other antihypertensives, nitrates.
- Cimetidine increases labetalol plasma levels.
- May antagonize beta-2 agonists (e.g., albuterol).
- Glutethimide may reduce labetalol bioavailability.
- Halothane anesthesia may enhance hypotensive and AV-blocking effects.
- Use cautiously with calcium channel blockers due to additive AV conduction effects.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Maintain regular scheduling to ensure stable blood pressure control.
Overdose
Symptoms may include severe hypotension, bradycardia, bronchospasm, and cardiac failure. Treatment is supportive: administer IV fluids, atropine for bradycardia, beta-agonists for bronchospasm, and glucagon if necessary. Hemodialysis is not effective due to high protein binding.
Storage
Store at room temperature (15–30°C), protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and individualized dosing. Do not discontinue or adjust medication without medical supervision.
Reviews
“Trandate has been a cornerstone in our hypertensive clinic for patients requiring nuanced blood pressure control. Its dual mechanism offers reliability especially in patients with tachycardia-predominant hypertension.” — Dr. Eleanor Vance, Cardiologist
“After trying several antihypertensives, Trandate provided the most consistent control with fewer side effects. The twice-daily dosing is manageable.” — Patient, 58
“Useful in perioperative settings for rapid blood pressure control. The IV formulation is predictably effective when oral agents are not feasible.” — Dr. Marcus Thorne, Anesthesiologist