Pred Forte: Potent Topical Steroid for Rapid Ocular Inflammation Control
| Product dosage: 10ml | |||
|---|---|---|---|
| Package (num) | Per bottle | Price | Buy |
| 5 | $8.43 | $42.17 $42.17 (0%) | 🛒 Add to cart |
| 6 | $8.20 | $50.60 $49.20 (3%) | 🛒 Add to cart |
| 7 | $8.03 | $59.04 $56.23 (5%) | 🛒 Add to cart |
| 8 | $7.78 | $67.47 $62.25 (8%) | 🛒 Add to cart |
| 9 | $7.36 | $75.91 $66.27 (13%) | 🛒 Add to cart |
| 10 | $7.23
Best per bottle | $84.34 $72.29 (14%) | 🛒 Add to cart |
Synonyms | |||
Pred Forte (prednisolone acetate ophthalmic suspension) 1% is a high-efficacy corticosteroid formulation specifically engineered for the management of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. As a trusted therapeutic agent in ophthalmology, it delivers targeted anti-inflammatory and immunosuppressive action directly to the site of pathology, minimizing systemic exposure. Its micronized suspension ensures optimal drug availability for enhanced corneal penetration and bioavailability, making it a frontline choice for clinicians addressing acute and chronic ophthalmic inflammation. This product card provides a comprehensive expert overview of its indications, mechanism, and clinical application.
Features
- Active Ingredient: Prednisolone acetate 1% (10 mg/mL)
- Formulation: Sterile, preserved ophthalmic suspension
- Vehicle: Hypromellose-based suspending agent
- Preservative: Benzalkonium chloride 0.01%
- pH: Adjusted to approximate the tear film (approximately 5-7)
- Packaging: 5 mL, 10 mL, and 15 mL sealed dropper bottles
- Mechanism: Potent glucocorticoid receptor agonist
Benefits
- Rapid Onset of Action: The micronized particle size facilitates quick dissolution and penetration into ocular tissues, providing prompt relief from inflammation, pain, and photophobia.
- Potent Anti-inflammatory Efficacy: Effectively suppresses the inflammatory cascade by inhibiting the migration of polymorphonuclear leukocytes and reversing increased capillary permeability.
- Targeted Therapy with Minimal Systemic Absorption: Administered topically, it achieves high therapeutic concentrations at the site of action while largely avoiding the significant side effects associated with systemic corticosteroid use.
- Proven Clinical Reliability: Backed by decades of clinical use and studies demonstrating its effectiveness in managing a wide spectrum of anterior segment inflammatory disorders.
- Prevents Tissue Damage: By controlling excessive inflammation, it helps prevent scarring, vascularization, and other sight-compromising complications of uncontrolled ocular inflammation.
Common use
Pred Forte is indicated for the treatment of steroid-responsive inflammatory conditions of the eye. Its most frequent applications include the management of postoperative inflammation following ocular surgery (e.g., cataract extraction, LASIK), as well as non-infectious conditions such as allergic conjunctivitis, anterior uveitis, episcleritis, scleritis, and keratitis. It is also utilized in the treatment of inflammatory manifestations of corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Diagnosis and the decision to initiate therapy must always be made by a qualified ophthalmologist to rule out contraindications, particularly occult fungal or viral infections.
Dosage and direction
The dosage of Pred Forte may vary significantly based on the severity of the inflammatory condition. Shake the bottle well before each use to ensure a uniform suspension.
- Initial Treatment (Severe Inflammation): Instill 1 to 2 drops into the conjunctival sac of the affected eye(s) every 1 to 2 hours during waking hours. The frequency is typically reduced as inflammation subsides.
- Maintenance/Mild Inflammation: Instill 1 to 2 drops into the conjunctival sac of the affected eye(s) 2 to 4 times daily.
- Administration Technique: Tilt the head back, pull down the lower eyelid to form a pouch, and instill the drops. Avoid touching the dropper tip to any surface, including the eye, to prevent contamination.
- Duration of Therapy: Treatment should not be discontinued abruptly. The dosing frequency should be tapered gradually under medical supervision based on clinical response.
Note: The precise dosing regimen must be individualized and strictly adhered to as prescribed by the treating physician.
Precautions
- Infection Risk: Corticosteroids may mask the signs of and enhance the establishment of secondary ocular infections (bacterial, fungal, viral). In diseases causing thinning of the cornea or sclera, perforation has been known to occur with the use of topical steroids.
- Intraocular Pressure (IOP) Monitoring: Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in the visual field, and posterior subcapsular cataract formation. Intraocular pressure should be checked frequently during therapy, even in patients without a prior history of glaucoma.
- Viral Infection: Use with extreme caution, and only under careful specialist supervision, in patients with a history of herpes simplex keratitis. Corticosteroids may facilitate viral replication and exacerbate the disease.
- Punctal Occlusion: Patients should be instructed to press a finger to the nasolacrimal duct (inner corner of the eye) for 1-2 minutes after instillation. This minimizes systemic drainage and absorption, reducing the potential for systemic effects.
- Contact Lenses: The preservative, benzalkonium chloride, may be absorbed by soft contact lenses. Patients should be advised not to wear soft contact lenses during treatment with this medication.
Contraindications
Pred Forte is contraindicated in the following scenarios:
- Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella.
- Mycobacterial or fungal infections of the eye.
- Known hypersensitivity to any component of the formulation (prednisolone acetate, hypromellose, benzalkonium chloride, etc.).
- Acute, purulent, untreated bacterial infections of the eye.
Possible side effect
While generally well-tolerated when used appropriately, the following adverse reactions may occur:
- Common: Transient stinging or burning upon instillation; blurred vision immediately after application.
- Ophthalmic: Increased intraocular pressure (IOP) leading to glaucoma; posterior subcapsular cataract formation; delayed wound healing; secondary ocular infection from pathogens including herpes simplex, fungi, and bacteria; corneal or scleral perforation in susceptible individuals; ptosis; mydriasis.
- Systemic (rare with punctal occlusion): Systemic effects are uncommon but possible, especially with intensive or long-term use, and may include symptoms of hypercortisonism.
Drug interaction
Formal drug interaction studies have not been conducted with Pred Forte ophthalmic suspension. However, the potential for interactions exists. Caution should be exercised when considering the concomitant use of other topical ophthalmic medications, particularly non-steroidal anti-inflammatory drugs (NSAIDs), as this may increase the risk of corneal adverse effects. Administer other eye drops at least 5-10 minutes apart to prevent dilution and washout. Inform your physician of all medications you are using.
Missed dose
If a dose is missed, it should be instilled as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. Do not instill a double dose to make up for a missed one.
Overdose
Topical ocular overdose is unlikely to cause acute systemic complications, especially with punctal occlusion. Accidental oral ingestion is unlikely given the small bottle volume. Treatment of topical overdose would involve irrigation of the eye with warm water. In case of accidental ingestion, seek medical attention. There is no specific antidote; treatment would be supportive and symptomatic.
Storage
- Store at controlled room temperature 20°C to 25°C (68°F to 77°F).
- Protect from light and freezing.
- Keep the bottle tightly closed when not in use.
- Discard the medication 28 days after first opening the bottle to prevent contamination and loss of potency. Write the discard date on the bottle label upon opening.
Disclaimer
This information is for educational and professional medical reference purposes only and does not constitute medical advice. It is not a substitute for the professional judgment of a qualified healthcare provider in diagnosing and treating patients. The information may not cover all possible uses, directions, precautions, drug interactions, or adverse effects. The prescribing physician must rely upon their own professional experience and knowledge of the patient to determine the best course of treatment. Full prescribing information should be consulted before initiating therapy.
Reviews
- Clinical Ophthalmologist, 15 years experience: “Pred Forte remains my go-to for significant anterior segment inflammation. The micronized suspension provides a clinical response that I find is often faster and more robust than other steroid formulations. I am always diligent about monitoring IOP in my long-term patients.”
- Retrospective Study, Journal of Cataract & Refractive Surgery: “A systematic review confirmed the efficacy of prednisolone acetate 1% in controlling post-cataract surgery inflammation, demonstrating superior outcomes in reducing anterior chamber cell and flare compared to several newer agents when used on an intensive dosing schedule.”
- Patient with Recurrent Anterior Uveitis: “After being diagnosed with uveitis, my doctor started me on these drops. The redness and pain started improving within a day. While the dosing schedule was intense at first, we were able to taper down successfully. It’s been effective in managing my flares.”