Poxet: Clinically Proven Premature Ejaculation Management
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Synonyms | |||
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Poxet represents a significant advancement in the pharmacological management of premature ejaculation (PE), offering a targeted and effective solution for a condition that profoundly impacts quality of life. This selective serotonin reuptake inhibitor (SSRI), with dapoxetine hydrochloride as its active pharmaceutical ingredient, is specifically designed for on-demand use to delay ejaculation and improve control. Developed through rigorous clinical research, it addresses the neurobiological pathways involved in the ejaculatory reflex, providing a reliable option for men seeking to enhance sexual performance and satisfaction. Its approval and use in numerous international markets underscore its established efficacy and safety profile within a structured treatment plan.
Features
- Active ingredient: Dapoxetine hydrochloride
- Available dosages: 30 mg and 60 mg film-coated tablets
- Rapid onset of action, typically within 1-2 hours post-administration
- Short elimination half-life, minimizing long-term systemic exposure
- Formulated for on-demand (prn) use, not requiring daily dosing
- Manufactured under strict GMP (Good Manufacturing Practice) standards
Benefits
- Significantly increases intravaginal ejaculatory latency time (IELT)
- Enhances perceived control over ejaculation
- Improves sexual satisfaction for both the patient and their partner
- Reduces personal distress and interpersonal difficulty related to PE
- Provides a flexible, non-daily dosing regimen suited to spontaneous sexual activity
- Supported by a substantial body of evidence from randomized controlled trials
Common use
Poxet is indicated for the treatment of premature ejaculation in adult men aged 18 to 64 years. It is prescribed for patients who exhibit a persistent or recurrent pattern of ejaculation occurring within approximately one minute of vaginal penetration (lifelong PE) or a clinically significant reduction in latency time, often to three minutes or less (acquired PE), prior to wishing it. This pattern must cause marked distress or interpersonal difficulty and cannot be attributed exclusively to the direct effects of a substance or another medical condition. Diagnosis should be based on a thorough medical and sexual history, often utilizing validated tools like the Premature Ejaculation Diagnostic Tool (PEDT).
Dosage and direction
The recommended starting dose is 30 mg, taken orally as a single dose approximately 1 to 3 hours prior to anticipated sexual activity. The tablet should be swallowed whole with a full glass of water; it can be taken with or without food, although a light meal may help mitigate potential nausea. Based on efficacy and tolerability, the dose may be increased to a maximum of 60 mg. It is advised not to take more than one dose within a 24-hour period. The need for continued treatment should be reassessed by a healthcare provider periodically, typically every 6 months, to evaluate the benefit-risk profile.
Precautions
Prior to initiation, a medical evaluation should be conducted to confirm the diagnosis of PE and rule out other sexual dysfunctions. Use with caution in patients with a history of mood disorders, as SSRIs can potentially induce or exacerbate symptoms. Patients should be monitored for the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania. Caution is advised in patients with conditions that may predispose them to hypotension or syncope, such as those with a history of fainting spells or orthostatic hypotension. Patients should avoid potentially hazardous activities, including driving, until they know how Poxet affects them, due to the risk of dizziness or syncope.
Contraindications
Poxet is contraindicated in patients with known hypersensitivity to dapoxetine or any of the excipients in the formulation. Its use is prohibited in patients with significant cardiac conditions, including heart failure (NYHA Class II-IV), conduction abnormalities (e.g., sick sinus syndrome, sinoatrial or AV block), significant ischemic heart disease, or a history of stroke. Concomitant administration with monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of serotonin syndrome, and a washout period of at least 14 days is required after discontinuing an MAOI before starting Poxet. Similarly, Poxet must not be used concomitantly with thioridazine, other SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), antipsychotics, or other central nervous system active drugs that affect serotonin levels. It is also contraindicated in patients with severe hepatic impairment.
Possible side effects
Like all medications, Poxet can cause side effects, although not everybody gets them. The most commonly reported adverse reactions are mild to moderate in intensity and often diminish with continued use. These include:
- Very common (≥1/10): dizziness, nausea, headache.
- Common (≥1/100 to <1/10): insomnia, somnolence, fatigue, anxiety, blurred vision, vomiting, diarrhea, constipation, abdominal pain, dry mouth, hyperhidrosis (increased sweating).
- Uncommon (≥1/1,000 to <1/100): syncope (fainting), tremor, tinnitus, palpitations, tachycardia, orthostatic hypotension, erectile dysfunction, decreased libido, flushing.
- Rare (<1/1,000): priapism, angle-closure glaucoma, serotonin syndrome, hypertensive crisis, aggression.
Patients should be advised to report any persistent or severe side effects to their healthcare provider.
Drug interaction
Dapoxetine is primarily metabolized by multiple CYP enzymes, including CYP3A4, CYP2D6, and others, making it susceptible to numerous drug interactions. Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin) significantly increase dapoxetine exposure and are contraindicated. Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole, diltiazem) require a maximum dose limitation of 30 mg. Concomitant use with potent CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) also necessitates a maximum dose of 30 mg. Concurrent use with other serotonergic drugs (other SSRIs, SNRIs, triptans, tramadol, tryptophan, St. John’s Wort) increases the risk of serotonin syndrome. Use with alcohol is not recommended due to increased risk of adverse events like dizziness and syncope. Concomitant use with alpha-blockers for BPH or antihypertensives may potentiate orthostatic hypotension. A comprehensive review of all concomitant medications, including over-the-counter drugs and herbal supplements, is essential before prescribing.
Missed dose
As Poxet is taken on an as-needed basis prior to sexual activity, the concept of a “missed dose” does not apply in the traditional sense. If a dose is not taken within the recommended time frame before intercourse, it should be omitted. The patient should not take a double dose to make up for a missed one. The next dose can be taken as needed for subsequent sexual activity, adhering to the 24-hour dosing interval.
Overdose
In the event of overdose, which may involve doses higher than 60 mg, supportive measures should be instituted. Symptoms are likely to be an extension of the known adverse reaction profile and may include serotonin syndrome (agitation, confusion, diaphoresis, tachycardia, hyperthermia, nausea, vomiting, tremors, hyperreflexia), syncope, dizziness, nausea, vomiting, and tachycardia. There is no specific antidote for dapoxetine overdose. Treatment consists of monitoring vital signs and providing appropriate supportive care, which may include ECG monitoring due to the potential for QT interval prolongation. Gastric lavage and administration of activated charcoal may be considered if presented early after ingestion.
Storage
Store in the original blister package at room temperature (below 25°C or 77°F), in a dry place, protected from light and moisture. Keep out of reach and sight of children. Do not use after the expiration date printed on the packaging. Do not dispose of medication via wastewater or household waste; return any unused or expired medication to a pharmacy for proper disposal in accordance with local regulations.
Disclaimer
This information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The efficacy and safety profile described are based on clinical trial data and prescribing information; individual patient experiences may vary.
Reviews
Clinical studies and patient-reported outcomes consistently demonstrate the efficacy of dapoxetine in the management of premature ejaculation. A meta-analysis of randomized, double-blind, placebo-controlled trials showed a 2.5 to 3.0-fold increase in IELT compared to placebo. Patient global impression of change (PGI-C) scores indicate that a significant majority of men report “much improved” or “very much improved” control over ejaculation and satisfaction with sexual intercourse. Partner surveys often corroborate these improvements in sexual experience. The most frequently cited benefits in real-world settings are the rapid onset of action and the flexibility of the on-demand regimen, which aligns well with spontaneous sexual activity. While side effects are reported, they are generally described as manageable and often transient, leading to high rates of treatment continuation among responders.