Nizagara: Advanced Sildenafil Citrate for Erectile Dysfunction
| Product dosage: 100mg | |||
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| Package (num) | Per pill | Price | Buy |
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| Product dosage: 25mg | |||
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| Product dosage: 50mg | |||
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Synonyms | |||
Similar products
Nizagara represents a significant advancement in the pharmacological management of erectile dysfunction (ED), offering a reliable and clinically-proven solution for men seeking to restore sexual function. This medication contains sildenafil citrate, a potent phosphodiesterase type 5 (PDE5) inhibitor that facilitates increased blood flow to the penile tissues, enabling firm and sustainable erections when sexually stimulated. Developed with stringent quality standards, Nizagara ensures bioequivalence to leading brand-name formulations while providing a cost-effective alternative. Its rapid onset of action and well-characterized safety profile make it a first-line therapeutic option recommended by urologists and sexual health specialists worldwide for the treatment of organic, psychogenic, and mixed-etiology ED.
Features
- Contains 100 mg of sildenafil citrate per tablet
- Film-coated formulation for easier swallowing
- Rapid disintegration time (approximately 15-30 minutes)
- High bioavailability with peak plasma concentrations reached within 30-120 minutes
- Manufactured in FDA-approved facilities following cGMP standards
- Available in convenient blister packaging ensuring product integrity
- Demonstrated stability under recommended storage conditions
Benefits
- Achieves and maintains erections sufficient for satisfactory sexual activity
- Provides reliable results with proper sexual stimulation
- Offers flexibility in timing due to 4-6 hour effective window
- Improves confidence and sexual relationship satisfaction
- Cost-effective alternative to brand-name medications
- Backed by extensive clinical research and real-world evidence
Common use
Nizagara is primarily prescribed for the treatment of erectile dysfunction in adult males. It is indicated for patients experiencing difficulty achieving or maintaining an erection sufficient for satisfactory sexual performance. The medication may be used by men with various underlying conditions contributing to ED, including diabetes mellitus, hypertension, cardiovascular disease (in stable patients), depression, and spinal cord injuries. It is also prescribed for psychogenic erectile dysfunction where performance anxiety or stress contributes to sexual dysfunction. Many patients use Nizagara on an as-needed basis before anticipated sexual activity, though some treatment regimens may involve scheduled dosing based on physician recommendation.
Dosage and direction
The recommended starting dose of Nizagara is 50 mg taken approximately 30-60 minutes before sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The medication should be taken orally with a glass of water and may be taken with or without food, though high-fat meals may delay onset of action. The dosing frequency should not exceed once per 24-hour period. For elderly patients (65 years and older) or those with hepatic impairment or severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 25 mg is recommended. The tablet should not be divided, crushed, or chewed as this may affect the drug’s release characteristics.
Precautions
Patients should undergo a thorough medical assessment before initiating Nizagara therapy, including cardiovascular evaluation due to the mild systemic vasodilatory effects. Sexual activity presents a potential cardiac risk, particularly in patients with pre-existing cardiovascular disease. Use with caution in patients with anatomical penile deformation, conditions that may predispose to priapism, bleeding disorders, or active peptic ulceration. Ophthalmic examinations are recommended for patients with retinitis pigmentosa or other hereditary retinal disorders. Patients should be advised that Nizagara offers no protection against sexually transmitted diseases. Alcohol consumption should be moderated as it may increase the risk of orthostatic hypotension. Grapefruit juice should be avoided as it may increase sildenafil concentrations.
Contraindications
Nizagara is absolutely contraindicated in patients using any form of organic nitrates or nitric oxide donors, either regularly or intermittently, due to the risk of profound hypotension. Additional contraindications include hypersensitivity to sildenafil citrate or any component of the formulation, severe hepatic impairment, hypotension (resting systolic BP <90 mmHg or diastolic BP <50 mmHg), recent stroke or myocardial infarction, unstable angina, hereditary degenerative retinal disorders, and non-arteritic anterior ischemic optic neuropathy. The medication is not indicated for use in women, children, or neonates. Concomitant use with potent CYP3A4 inhibitors requires extreme caution and dose adjustment.
Possible side effects
The most commonly reported adverse reactions are headache (16%), flushing (10%), dyspepsia (7%), nasal congestion (4%), and dizziness (3%). Visual disturbances including blurred vision, cyanopsia, and photophobia occur in approximately 3% of users. Less frequent side effects include back pain, myalgia, nausea, rash, and palpitations. Serious but rare adverse events include priapism, sudden hearing loss, cardiovascular events, and severe hypotension. Most side effects are dose-dependent and transient, typically resolving within several hours. Patients experiencing erection lasting more than 4 hours should seek immediate medical attention to prevent potential penile tissue damage.
Drug interaction
Nizagara demonstrates significant interactions with nitrates, alpha-blockers, antihypertensive medications, and CYP3A4 inhibitors. Concomitant use with organic nitrates is absolutely contraindicated. Caution is required when co-administering with alpha-adrenergic blocking agents due to additive blood pressure-lowering effects. Potent CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, and erythromycin may significantly increase sildenafil concentrations, requiring dose reduction. Moderate interactions occur with other antihypertensive agents, CYP3A4 inducers (rifampin, carbamazepine), and grapefruit juice. Limited data exists regarding interactions with other PDE5 inhibitors, which should be avoided.
Missed dose
As Nizagara is prescribed for use as needed before sexual activity, the concept of a “missed dose” does not apply in the conventional sense. Patients should simply take the medication approximately 30-60 minutes before anticipated sexual activity when needed. There is no need to make up for a missed dose, and patients should not take additional tablets to compensate for previously missed opportunities for sexual activity. The medication should never be taken more than once in a 24-hour period regardless of timing of sexual activity or perceived need.
Overdose
In cases of overdose exceeding the maximum recommended dose, patients may experience severe manifestations of the drug’s known adverse effects, including severe hypotension, syncope, prolonged erection, and potentially cardiovascular complications. Management should include supportive measures with maintenance of blood pressure through fluid administration and positioning. Hemodialysis is not expected to significantly accelerate clearance as sildenafil is highly protein-bound and extensively metabolized. Priapism lasting more than 4 hours requires urgent urological intervention to prevent permanent tissue damage. Symptomatic treatment for headache, flushing, and gastrointestinal distress may be provided as needed.
Storage
Nizagara tablets should be stored at room temperature between 15-30°C (59-86°F) in their original packaging to protect from light and moisture. The medication should be kept in a secure location out of reach of children and pets. Tablets should not be used beyond the expiration date printed on the packaging. Do not transfer tablets to alternative containers as this may compromise stability and protection from environmental factors. Avoid storage in bathrooms or other areas with high humidity or temperature fluctuations.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Nizagara is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Patients must consult with their physician for proper diagnosis and treatment recommendations based on individual health status and medical history. The manufacturer and distributors are not liable for any adverse outcomes resulting from improper use, self-diagnosis, or failure to follow prescribed instructions. Always read the accompanying patient information leaflet for complete safety information.
Reviews
Clinical studies demonstrate that approximately 82% of men with erectile dysfunction reported improved erections with sildenafil citrate compared to 24% on placebo. Real-world evidence from urology practices indicates high patient satisfaction with Nizagara, particularly regarding its reliability and cost-effectiveness compared to brand-name alternatives. Patients frequently report improved sexual confidence and relationship satisfaction. Some users note the importance of proper timing and avoiding high-fat meals for optimal results. The majority of adverse effects are reported as mild and transient, with discontinuation rates due to side effects remaining below 3% in most studies.