Lasix: Effective Diuretic for Fluid Overload Management
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.52 | $45.20 (0%) | 🛒 Add to cart |
| 20 | $2.51 | $90.40 $50.22 (44%) | 🛒 Add to cart |
| 30 | $1.84 | $135.61 $55.25 (59%) | 🛒 Add to cart |
| 60 | $1.00 | $271.21 $60.27 (78%) | 🛒 Add to cart |
| 90 | $0.78 | $406.82 $70.31 (83%) | 🛒 Add to cart |
| 120 | $0.67 | $542.42 $80.36 (85%) | 🛒 Add to cart |
| 180 | $0.50 | $813.64 $90.40 (89%) | 🛒 Add to cart |
| 270 | $0.45 | $1220.46 $120.54 (90%) | 🛒 Add to cart |
| 360 | $0.39
Best per pill | $1627.27 $140.63 (91%) | 🛒 Add to cart |
Similar products
Lasix (furosemide) is a potent loop diuretic widely prescribed for the management of edema associated with congestive heart failure, liver cirrhosis, and renal disease. By inhibiting sodium and chloride reabsorption in the ascending loop of Henle, it promotes significant fluid elimination, reduces preload, and alleviates symptoms of fluid retention. Its rapid onset and predictable pharmacokinetic profile make it a cornerstone therapy in both acute and chronic settings where prompt diuresis is required.
Features
- Active ingredient: Furosemide 20 mg, 40 mg, or 80 mg tablets; also available in intravenous formulation
- Mechanism: Selective inhibition of the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle
- Onset of action: Oral: 30–60 minutes; IV: within 5 minutes
- Peak effect: 1–2 hours (oral); 30 minutes (IV)
- Duration: 6–8 hours
- Bioavailability: Approximately 60–70%
- Half-life: 1.5–2 hours (prolonged in renal impairment)
- Excretion: Primarily renal (80%), with some hepatic metabolism
Benefits
- Rapid and effective reduction of edema in heart failure, hepatic, and renal conditions
- Lowers ventricular filling pressures, reducing symptoms of pulmonary congestion and dyspnea
- Helps control hypertension through volume reduction and mild vasodilatory effects
- Facilitates management of hypercalcemia by promoting calcium excretion
- Useful in acute pulmonary edema and ascites where prompt fluid removal is critical
- May improve renal perfusion in select cases of acute kidney injury when used appropriately
Common use
Lasix is primarily indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disorders, including nephrotic syndrome. It is also used in the management of hypertension, either alone or in combination with other antihypertensive agents. Off-label uses include treatment of hypercalcemia and, in some cases, altitude sickness. In critical care settings, intravenous Lasix is employed for acute decompensated heart failure and to facilitate fluid removal in oliguric states.
Dosage and direction
Dosage must be individualized based on patient response, renal function, and clinical context. For edema in adults: initial oral dose is 20–80 mg once daily, which may be increased by 20–40 mg every 6–8 hours until desired diuretic effect is achieved. Maintenance doses range from 20 mg to 600 mg daily, often given as a single dose or in divided doses. For hypertension:起始剂量通常为40 mg每日两次，可根据反应调整。静脉给药用于急性情况或当口服不可行时：通常起始剂量为20–40 mg，可重复或递增。给药时间宜在早晨或午后早期以避免夜间多尿。患者应定期监测体重、电解质和肾功能以指导剂量调整。
Precautions
Monitor serum electrolytes (particularly potassium, sodium, and magnesium), BUN, creatinine, and uric acid regularly, especially during initial therapy or after dose changes. Use with caution in patients with hepatic cirrhosis or ascites due to risk of electrolyte imbalance precipitating hepatic encephalopathy. Ototoxicity is a risk, particularly with rapid IV administration, high doses, or concomitant use of other ototoxic drugs. Photosensitivity reactions may occur. Elderly patients may be more susceptible to volume depletion and hypotension. Avoid use in severe sulfonamide allergy.
Contraindications
Lasix is contraindicated in patients with anuria or known hypersensitivity to furosemide or sulfonamide-derived drugs. It is also contraindicated in hepatic coma or severe electrolyte depletion until the condition improves or is corrected. Avoid use in patients with documented sulfa allergy. Not recommended during pregnancy unless potential benefit justifies potential risk to the fetus.
Possible side effect
Common side effects include dehydration, hypokalemia, hyponatremia, hypochloremic alkalosis, hypotension, hyperglycemia, and hyperuricemia. Ototoxicity (tinnitus, hearing loss) may occur, especially with rapid IV injection or high doses. Gastrointestinal disturbances such as nausea, vomiting, or diarrhea are possible. Less frequently, pancreatitis, blood dyscrasias, thrombophlebitis after IV use, skin photosensitivity, or systemic vasculitis may occur.
Drug interaction
Lasix may potentiate the effects of other antihypertensive agents. Concomitant use with aminoglycosides, cisplatin, or other ototoxic drugs increases risk of hearing loss. NSAIDs may reduce its diuretic and antihypertensive effects. It may enhance nephrotoxicity when combined with cephalosporins or other nephrotoxic agents. Corticosteroids and amphotericin B increase the risk of hypokalemia. Lithium excretion may be reduced, increasing risk of toxicity. Probeneciд may decrease diuretic efficacy.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next dose. In that case, skip the missed dose and resume the regular schedule. Do not double the dose. Consistent timing helps maintain stable fluid balance, though occasional missed doses are unlikely to cause significant clinical deterioration in chronic management.
Overdose
Symptoms of overdose include profound water and electrolyte depletion (manifested as weakness, dizziness, confusion, arrhythmias, muscle cramps), dehydration, and circulatory collapse. Treatment is supportive and includes electrolyte replacement and volume resuscitation. Hemodialysis does not effectively remove furosemide. Monitor fluid status, electrolytes, and vital signs closely.
Storage
Store at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep in the original container, tightly closed. Do not use if tablets are discolored or show signs of deterioration. Keep out of reach of children and pets.
Disclaimer
This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting or changing any medication regimen. Dosage and indications may vary based on individual patient factors and regional prescribing guidelines.
Reviews
Lasix is consistently rated highly among clinicians for its efficacy in managing fluid overload in heart failure and renal impairment. Critical care specialists appreciate its rapid onset and titratability in acute settings. Some reviews note the necessity for careful electrolyte monitoring, particularly in long-term use. Patients often report significant improvement in breathing and swelling, though some mention increased urination as a challenging side effect. Overall, it remains a first-line agent in diuretic therapy due to its reliability and well-understood profile.