Isotroin: The Clinically Proven Acne Treatment Solution
| Product dosage: 30mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $1.19 | $71.29 (0%) | 🛒 Add to cart |
| 90 | $1.15 | $106.93 $103.41 (3%) | 🛒 Add to cart |
| 120 | $1.09 | $142.57 $130.52 (8%) | 🛒 Add to cart |
| 180 | $0.99 | $213.86 $178.71 (16%) | 🛒 Add to cart |
| 270 | $0.95 | $320.78 $257.03 (20%) | 🛒 Add to cart |
| 360 | $0.92
Best per pill | $427.71 $331.32 (23%) | 🛒 Add to cart |
Synonyms
| |||
Isotroin is a prescription medication containing isotretinoin, a powerful retinoid derived from vitamin A, designed for the treatment of severe, recalcitrant nodular acne that has not responded to conventional therapies. It functions by targeting multiple pathogenic factors of acne, including sebum production, follicular hyperkeratinization, inflammation, and Cutibacterium acnes proliferation. Administered under strict medical supervision due to its potent effects and potential side effects, Isotroin offers a transformative approach for patients with disfiguring or persistent acne conditions. This treatment requires careful patient selection, monitoring, and adherence to safety protocols to maximize efficacy and minimize risks.
Features
- Contains isotretinoin as the active ingredient in strengths of 10 mg, 20 mg, or 40 mg per soft gelatin capsule
- Formulated for oral administration with lipid-enhanced absorption
- Manufactured under strict pharmaceutical quality control standards
- Provided in blister packs with clear dosing instructions and safety warnings
- Requires prescription and enrollment in a risk management program (e.g., iPledge in the US)
Benefits
- Significantly reduces sebum production, leading to long-term remission of severe acne
- Decreases inflammation and prevents new comedone formation
- Improves skin texture and reduces the incidence of acne scarring
- Enhances psychological well-being and quality of life by resolving severe dermatological conditions
- Offers a finite treatment course, often resulting in prolonged or permanent clearance
- Addresses multiple acne pathophysiological mechanisms simultaneously
Common use
Isotroin is indicated for the treatment of severe recalcitrant nodular acne in patients aged 12 years and older who are unresponsive to standard acne treatments, including systemic antibiotics and topical therapies. It is also used off-label under specialist supervision for other conditions such as gram-negative folliculitis, rosacea, and certain disorders of keratinization. Treatment is typically initiated after a comprehensive dermatological evaluation and exclusion of contraindications.
Dosage and direction
The recommended dosage of Isotroin is based on body weight, usually 0.5 to 1.0 mg/kg per day, administered in two divided doses with food to enhance absorption. The total cumulative dose typically ranges from 120 to 150 mg/kg over a 15 to 20-week course. Dosage adjustments may be necessary based on treatment response and tolerability. It is crucial to swallow the capsules whole with a full glass of water and not to crush or chew them. Treatment courses are generally not repeated without a thorough risk-benefit assessment by a dermatologist.
Precautions
- Pregnancy prevention is mandatory: two reliable forms of contraception must be used one month before, during, and one month after therapy
- Regular monitoring of liver enzymes, lipids, and complete blood count is required before and during treatment
- Patients should avoid waxing, dermabrasion, or laser procedures during and for 6 months after therapy due to skin fragility
- Sun exposure should be minimized, and broad-spectrum sunscreen is recommended
- Mood changes, including depression, should be promptly reported to the healthcare provider
- Contact lens wearers may experience dry eyes and should use lubricating drops
Contraindications
- Pregnancy, lactation, or women of childbearing potential not using highly effective contraception
- Hypersensitivity to isotretinoin, other retinoids, or any component of the formulation
- Severely impaired liver function or uncontrolled hyperlipidemia
- Concomitant use of tetracycline antibiotics due to increased risk of pseudotumor cerebri
- Patients with a history of pancreatitis or hypervitaminosis A
Possible side effects
- Common: Dry skin, cheilitis, dry eyes, epistaxis, photosensitivity, musculoskeletal pain
- Serious: Psychiatric effects (depression, suicidal ideation), pseudotumor cerebri, hepatitis, pancreatitis, hypertriglyceridemia, teratogenicity
- Ocular: Conjunctivitis, night vision disturbances, corneal opacities
- Dermatological: Skin fragility, pruritus, rash, paronychia
- Gastrointestinal: Inflammatory bowel disease (rare association)
Drug interaction
- Tetracyclines: Increased risk of intracranial hypertension
- Vitamin A supplements: Additive toxic effects leading to hypervitaminosis A
- Corticosteroids: Potential increased risk of osteoporosis with long-term concomitant use
- Phenytoin: Isotretinoin may reduce serum levels of phenytoin
- St. John’s Wort: May reduce effectiveness of hormonal contraceptives
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. Doubling the dose to make up for a missed one is not recommended. Patients should maintain regular dosing intervals and consult their dermatologist if multiple doses are missed to discuss potential adjustments to the treatment plan.
Overdose
Symptoms of Isotroin overdose resemble acute hypervitaminosis A, including vomiting, facial flushing, cheilitis, abdominal pain, headache, dizziness, and ataxia. Management is supportive and symptomatic; there is no specific antidote. Gastric lavage may be considered if ingestion is recent. Patients should seek immediate medical attention and bring the medication packaging for identification.
Storage
Store Isotroin capsules at room temperature (15-30°C) in their original blister packaging, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Unused medication should be disposed of properly according to local regulations or through a drug take-back program.
Disclaimer
This information is for educational purposes only and does not replace professional medical advice. Isotroin is a prescription medication that must be used under the supervision of a qualified healthcare provider. Patients must adhere to all monitoring requirements and safety protocols. The manufacturer and prescribing physician should be consulted for full prescribing information and individual patient guidance.
Reviews
Clinical studies demonstrate that isotretinoin therapy achieves complete or near-complete clearance in approximately 85% of patients with severe nodular acne after a single 15-20 week course, with long-term remission rates exceeding 70%.
Patient-reported outcomes indicate significant improvements in quality of life measures, including social functioning and emotional well-being, though careful monitoring for adverse effects remains essential throughout treatment.