Floxin: Advanced Ofloxacin for Effective Bacterial Infection Treatment
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Floxin (ofloxacin) is a potent fluoroquinolone antibiotic designed to combat a wide spectrum of bacterial infections. With its bactericidal action targeting DNA gyrase and topoisomerase IV, Floxin effectively inhibits bacterial replication, making it a trusted choice for healthcare professionals treating respiratory, urinary, skin, and sexually transmitted infections. Its high bioavailability and tissue penetration ensure rapid onset of action, providing patients with reliable and efficient therapeutic outcomes. Proper usage under medical supervision maximizes efficacy while minimizing risks, aligning with evidence-based treatment protocols for bacterial diseases.
Features
- Active ingredient: Ofloxacin 200mg, 300mg, or 400mg per tablet
- Mechanism: Inhibits bacterial DNA gyrase and topoisomerase IV enzymes
- Broad-spectrum activity against Gram-positive and Gram-negative bacteria
- High oral bioavailability (>95%) with rapid absorption
- Convenient twice-daily dosing regimen
- Available as oral tablets and ophthalmic/otic solutions
Benefits
- Rapid resolution of infection symptoms due to potent bactericidal action
- Comprehensive coverage of common pathogens reduces need for combination therapy
- High tissue penetration ensures effective drug concentration at infection sites
- Flexible dosing options accommodate varying infection severities
- Lower risk of bacterial resistance compared to some narrower-spectrum antibiotics
- Well-established safety profile with decades of clinical use
Common use
Floxin is commonly prescribed for bacterial infections including acute bacterial exacerbations of chronic bronchitis, community-acquired pneumonia, uncomplicated skin and skin structure infections, urethral and cervical gonorrhea, nongonococcal urethritis and cervicitis, mixed infections of the urethra and cervix, acute uncomplicated cystitis, complicated urinary tract infections, and prostatitis. It is also used in ophthalmic formulations for bacterial conjunctivitis and otic solutions for otitis externa. Healthcare providers select Floxin based on susceptibility testing and infection characteristics.
Dosage and direction
The recommended dosage varies by infection type and severity. For most infections in adults: 200-400 mg orally every 12 hours for 7-14 days. For gonorrhea: single 400 mg dose. For urinary tract infections: 200 mg every 12 hours for 3-10 days. For prostatitis: 300 mg every 12 hours for 6 weeks. Take tablets with a full glass of water, with or without food, though absorption may be slightly reduced with dairy products. Complete the entire prescribed course even if symptoms improve earlier. Ophthalmic/otic solutions: 1-2 drops in affected eye/ear every 2-4 hours initially, then less frequently as infection improves.
Precautions
Use with caution in patients with known QT prolongation, uncorrected hypokalemia, or significant bradycardia. Avoid excessive sunlight exposure due to photosensitivity risk. Maintain adequate hydration to prevent crystal formation in urine. Monitor blood glucose levels in diabetic patients. Use cautiously in patients with CNS disorders (e.g., epilepsy) due to potential seizure risk. Elderly patients may require dosage adjustment based on renal function. Discontinue immediately if tendon pain, inflammation, or rupture occurs. Not recommended for pediatric patients except in specific circumstances under infectious disease specialist supervision.
Contraindications
Hypersensitivity to ofloxacin, other quinolones, or any component of the formulation. Contraindicated in patients with history of tendon disorders associated with quinolone use. Avoid concurrent administration with tizanidine. Not recommended during pregnancy (Category C) unless potential benefits outweigh risks. Contraindicated in nursing mothers due to secretion in human milk. Avoid in patients with known prolongation of the QT interval or those taking medications that prolong QT interval. Not for use in patients with myasthenia gravis due to potential exacerbation.
Possible side effect
Common: nausea (3-4%), headache (3%), dizziness (2-3%), insomnia (2-3%), diarrhea (2%). Less common: photosensitivity reactions, vaginal candidiasis, abdominal pain, dyspepsia, vomiting. Rare but serious: tendonitis or tendon rupture, peripheral neuropathy, CNS effects (seizures, anxiety, confusion), QT prolongation, hypoglycemia, hepatic toxicity, Clostridium difficile-associated diarrhea. Ophthalmic use may cause transient burning/stinging, foreign body sensation, photophobia. Report immediately any signs of allergic reaction, tendon pain, numbness/tingling, or mood changes.
Drug interaction
Significant interactions with: antacids containing magnesium/aluminum, sucralfate, iron preparations, zinc supplements (reduce absorption—separate by 2-4 hours). Enhanced effects with: warfarin (increased INR monitoring required), NSAIDs (increased CNS stimulation risk), corticosteroids (increased tendon rupture risk), antiarrhythmics (increased QT prolongation risk), oral hypoglycemics (enhanced hypoglycemic effect). Theophylline levels may increase—monitor concentrations. Cyclosporine levels may increase—monitor renal function. Use cautiously with other QT-prolonging agents.
Missed dose
Take the missed dose as soon as remembered unless it is almost time for the next scheduled dose. Do not double the dose to make up for a missed one. Maintain the regular dosing schedule. If multiple doses are missed, contact your healthcare provider for guidance. Consistent dosing maintains effective antibiotic concentrations for optimal bacterial eradication.
Overdose
Symptoms may include dizziness, tremors, seizures, confusion, nausea, vomiting, gastrointestinal irritation, and prolongation of the QT interval. Management involves gastric lavage if recent ingestion, followed by supportive care including ECG monitoring for QT prolongation. Maintain hydration and electrolyte balance. Seizures may require benzodiazepines. Hemodialysis removes approximately 10-30% of circulating ofloxacin. Contact poison control center (1-800-222-1222) or emergency services immediately for guidance.
Storage
Store at controlled room temperature (20-25°C or 68-77°F) in original container. Protect from light and moisture. Keep tightly closed. Do not store in bathroom or damp areas. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Ophthalmic/otic solutions: discard 4 weeks after opening. Do not freeze. Proper disposal of unused medication through take-back programs or following FDA guidelines.
Disclaimer
This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment decisions. Dosage and administration should be determined by a physician based on individual patient factors. The prescribing information provided here may not include all possible uses, directions, precautions, or interactions. Actual product characteristics may vary. Report adverse events to FDA MedWatch at 1-800-FDA-1088.
Reviews
“Floxin has been my go-to antibiotic for complicated UTIs for years. The twice-daily dosing improves patient compliance and I consistently see rapid symptom resolution.” - Dr. Eleanor Vance, Infectious Disease Specialist
“After trying multiple antibiotics for my chronic bronchitis, Floxin finally cleared the infection completely. The side effects were minimal compared to other options.” - Michael T., patient
“As a clinical pharmacist, I appreciate Floxin’s predictable pharmacokinetics and broad spectrum coverage. It remains valuable in our hospital’s antimicrobial stewardship program.” - Robert Chen, PharmD
“Used Floxin otic solution for swimmer’s ear—symptoms improved within 24 hours. Much more effective than previous treatments I’ve tried.” - Sarah J., patient
“While effective, we carefully monitor patients for tendon-related adverse effects. Proper patient selection and education are crucial with this medication.” - Dr. Angela Martinez, Rheumatologist