Flagyl ER: Effective Extended-Release Treatment for Bacterial Infections
| Product dosage: 200mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 120 | $0.37 | $44.20 (0%) | 🛒 Add to cart |
| 180 | $0.31 | $66.30 $56.25 (15%) | 🛒 Add to cart |
| 270 | $0.28 | $99.45 $75.34 (24%) | 🛒 Add to cart |
| 360 | $0.26
Best per pill | $132.60 $93.42 (30%) | 🛒 Add to cart |
Flagyl ER (metronidazole extended-release) is a prescription antibiotic and antiprotozoal medication designed to treat a range of serious bacterial and parasitic infections. Its advanced extended-release formulation ensures consistent therapeutic levels in the body, enhancing efficacy while potentially reducing dosing frequency. It is specifically indicated for the treatment of bacterial vaginosis in non-pregnant females and is valued in clinical practice for its targeted antimicrobial action against anaerobic organisms.
Features
- Active ingredient: Metronidazole 750 mg
- Form: Extended-release tablet
- Mechanism: Disrupts DNA synthesis in susceptible anaerobic bacteria and protozoa
- Administration: Oral
- Manufacturer: Various FDA-approved pharmaceutical companies
- Available by prescription only
Benefits
- Provides sustained, controlled release of medication for consistent therapeutic effect
- Reduces bacterial load effectively in anaerobic infections
- May allow for less frequent dosing compared to immediate-release formulations
- Helps alleviate symptoms such as discharge, odor, and discomfort associated with bacterial vaginosis
- Supports recovery with a targeted spectrum of activity against susceptible pathogens
- Minimizes potential for dose-related peaks and troughs in plasma concentration
Common use
Flagyl ER is primarily prescribed for the treatment of bacterial vaginosis in adult women. It may also be used off-label or as part of combination therapy for other anaerobic bacterial infections, such as intra-abdominal infections, gynecologic infections, and certain protozoal infections, under careful medical supervision. Its use is determined based on culture results, susceptibility patterns, and clinical presentation.
Dosage and direction
The typical dosage for bacterial vaginosis is one 750 mg extended-release tablet taken orally once daily for 7 days. Tablets should be swallowed whole; do not crush, chew, or split. Administer with food to minimize gastrointestinal upset. Complete the full course of therapy even if symptoms improve earlier to prevent resistance and recurrence. Dosage adjustments may be necessary in patients with hepatic impairment.
Precautions
- Use with caution in patients with hepatic impairment; monitor liver function.
- Avoid alcohol consumption during treatment and for at least 3 days after completion due to risk of disulfiram-like reaction.
- May cause dizziness or drowsiness; advise patients to avoid driving or operating machinery until effects are known.
- Not recommended during pregnancy unless clearly needed; discuss risks and benefits with a healthcare provider.
- Use in pediatric patients has not been established for this formulation.
- Inform your healthcare provider of any history of blood disorders, seizures, or nervous system diseases.
Contraindications
- Hypersensitivity to metronidazole, nitroimidazole derivatives, or any component of the formulation.
- History of disulfiram use within the past 2 weeks.
- First trimester of pregnancy (relative contraindication; use only if potential benefit justifies potential risk).
Possible side effect
Common side effects may include nausea, headache, dry mouth, metallic taste, and gastrointestinal discomfort. Less frequently, patients may experience dizziness, drowsiness, darkened urine, or reversible peripheral neuropathy. Serious side effects such as seizures, encephalopathy, or severe skin reactions are rare but require immediate medical attention. Report any persistent or worsening symptoms to a healthcare provider.
Drug interaction
- Disulfiram: Concurrent use may cause psychotic reactions.
- Warfarin: Metronidazole may potentiate anticoagulant effect; monitor INR closely.
- Lithium: Increased risk of lithium toxicity.
- Alcohol: Risk of disulfiram-like reaction (flushing, nausea, vomiting).
- CYP450 inhibitors/inducers: May alter metronidazole metabolism.
- Inform your prescriber of all medications, including OTC drugs and supplements.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consult your pharmacist or healthcare provider for specific guidance based on timing.
Overdose
Symptoms of overdose may include nausea, vomiting, ataxia, seizures, and peripheral neuropathy. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion was recent. Seek immediate medical attention or contact a poison control center.
Storage
Store at room temperature (20–25°C or 68–77°F) in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized medical guidance. Do not initiate, adjust, or discontinue medication without consulting a qualified professional.
Reviews
“Flagyl ER provided effective relief for my bacterial vaginosis with once-daily dosing. The extended-release formulation was convenient and caused fewer GI side effects than the immediate-release version I had taken previously.” – Maria, 34
“As a clinician, I appreciate the pharmacokinetic profile of Flagyl ER for appropriate patients. It offers reliable coverage with improved adherence potential, though patient education on alcohol avoidance remains critical.” – Dr. Evans, Infectious Disease Specialist