Duphalac: Gentle and Effective Relief for Chronic Constipation
Duphalac is a clinically proven osmotic laxative containing lactulose, designed to provide predictable and gentle relief from chronic constipation. It works by drawing water into the colon, softening stools and stimulating natural bowel movements without causing harsh urgency or irritation. Trusted by healthcare professionals worldwide, Duphalac helps restore regular bowel function and improve quality of life for those struggling with persistent constipation.
Features
- Active ingredient: Lactulose (670 mg/mL)
- Form: Oral solution or sachets
- Mechanism: Osmotic laxative
- Non-systemic, works locally in the colon
- Sugar-free formulation available
- Suitable for long-term use under medical supervision
Benefits
- Promotes soft, easy-to-pass stools reducing straining
- Helps restore and maintain regular bowel habits
- Minimizes risk of bowel dependency compared to stimulant laxatives
- Reduces abdominal discomfort associated with constipation
- Can help manage hepatic encephalopathy by reducing ammonia absorption
- Improves overall digestive comfort and quality of life
Common use
Duphalac is primarily indicated for the treatment of chronic constipation in adults, adolescents, and children when dietary and lifestyle measures prove insufficient. It is particularly valuable for patients who require long-term management of constipation, including elderly patients with reduced colonic motility, pregnant women (under medical supervision), and individuals with irritable bowel syndrome constipation-predominant (IBS-C). Additionally, Duphalac is used in the management and prevention of hepatic encephalopathy, where it helps reduce blood ammonia levels through its acidifying effect in the colon.
Dosage and direction
For constipation treatment in adults and adolescents: Initial dose of 15-30 mL (10-20 g lactulose) daily, adjusted to individual response. Maintenance dose typically ranges from 10-25 mL daily. For children: 5 mL daily for ages 7-14 years, 2.5-5 mL daily for ages 1-6 years. For hepatic encephalopathy: 30-45 mL three times daily, adjusted to produce 2-3 soft stools per day. Administer orally, preferably with meals. May be diluted with water or fruit juice to improve palatability. Effects typically occur within 24-48 hours of initial administration.
Precautions
Use with caution in patients with diabetes due to carbohydrate content (regular formulation). Monitor electrolyte balance during prolonged use in debilitated patients. Exercise caution in patients with lactose intolerance. Not recommended for use in patients requiring low galactose diets. Elderly and debilitated patients should be monitored for signs of dehydration. Discontinue use if abdominal pain, nausea, or vomiting persists or worsens. Consult healthcare provider before use during pregnancy or breastfeeding.
Contraindications
Hypersensitivity to lactulose or any components of the formulation. Galactosemia. Intestinal obstruction. Acute abdominal conditions including appendicitis, inflammatory bowel disease, or undiagnosed abdominal pain. Conditions where fluid accumulation in the intestine should be avoided. Not recommended for patients with galactose-free diet requirements.
Possible side effect
Common: Flatulence, abdominal distension, and cramping typically diminish with continued use. Less common: Nausea, vomiting, diarrhea (especially with excessive dosage). Rare: Electrolyte imbalance with prolonged excessive use, dehydration in vulnerable populations. Excessive diarrhea may lead to hypokalemia and hypernatremia. Allergic reactions are very rare but may include rash, itching, or difficulty breathing.
Drug interaction
May alter absorption of other oral medications administered concurrently—separate administration by at least 2 hours. May potentiate effects of non-potassium-sparing diuretics or corticosteroids due to possible potassium loss. Antacids may reduce effectiveness of lactulose. Caution with other laxatives due to potential for excessive bowel activity. Monitor blood glucose in diabetics using regular formulation.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed administration. Maintain regular dosing schedule once established. For once-daily regimens, if missed completely, resume normal schedule the following day.
Overdose
Symptoms include severe diarrhea, abdominal cramping, dehydration, and electrolyte disturbances (particularly hypokalemia). Treatment involves discontinuation of medication, rehydration with electrolyte solutions, and symptomatic management. Severe cases may require medical supervision and intravenous fluid replacement. Monitor electrolyte levels in significant overdose situations.
Storage
Store at room temperature (15-30°C). Keep container tightly closed. Protect from direct sunlight and excessive heat. Do not freeze. Keep out of reach of children. Discard any unused medication 6 months after opening the bottle. Do not use if solution appears discolored or contains particulate matter.
Disclaimer
This information is for educational purposes only and does not replace professional medical advice. Always consult with a healthcare provider before starting any new medication, especially if you have underlying medical conditions or are taking other medications. Dosage and treatment duration should be determined by a qualified healthcare professional based on individual patient needs.
Reviews
Clinical studies demonstrate Duphalac’s efficacy with 70-80% of patients achieving improved bowel frequency within one week of treatment. Gastroenterologists consistently rate lactulose as a first-line option for chronic constipation management due to its favorable safety profile. Patient satisfaction surveys indicate high rates of improved quality of life and preference over stimulant laxatives. Long-term studies show maintained efficacy with minimal side effect development over extended use periods.