Dapsone: Advanced Treatment for Dermatitis Herpetiformis & Acne
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per tab | Price | Buy |
| 1000 | $0.08 | $80.32 (0%) | 🛒 Add to cart |
| 2000 | $0.07 | $160.64 $140.56 (13%) | 🛒 Add to cart |
| 3000 | $0.06
Best per tab | $240.96 $180.72 (25%) | 🛒 Add to cart |
Dapsone is a sulfone antibiotic medication primarily indicated for the treatment of dermatitis herpetiformis and acne vulgaris. It functions through its potent anti-inflammatory and antibacterial properties, targeting neutrophil-mediated inflammation and suppressing microbial growth. This makes it a cornerstone in dermatological therapeutics, particularly for conditions resistant to first-line treatments. Its efficacy is well-documented in clinical literature, offering a specialized approach to managing chronic skin disorders.
Features
- Active Ingredient: Dapsone (diaminodiphenyl sulfone)
- Available Formulations: Oral tablets (25 mg and 100 mg) and topical gel (5%, 7.5%)
- Mechanism of Action: Inhibition of neutrophil chemotaxis and lysosomal enzyme release; bactericidal activity against Mycobacterium leprae and Propionibacterium acnes
- Half-Life: Approximately 20–30 hours
- Bioavailability: 70–80% following oral administration
- Metabolism: Hepatic, primarily via N-acetylation and N-hydroxylation
- Excretion: Renal (primarily) and fecal
Benefits
- Provides rapid and sustained relief from the intense pruritus and blistering associated with dermatitis herpetiformis.
- Reduces inflammatory papules, pustules, and nodules in moderate to severe acne vulgaris.
- Offers an alternative therapeutic option for patients unresponsive to or intolerant of conventional antibiotics or retinoids.
- Demonstrates a well-established safety profile with decades of clinical use and post-marketing surveillance.
- Can be used as a steroid-sparing agent in certain inflammatory dermatoses.
- Available in both systemic and topical formulations to suit varying patient needs and severity levels.
Common use
Dapsone is most commonly prescribed for dermatitis herpetiformis, a chronic, intensely pruritic skin disorder linked to gluten sensitivity. It is also widely used in the management of acne vulgaris, particularly in cases presenting with inflammatory lesions. Off-label uses include treatment for certain autoimmune bullous diseases (e.g., linear IgA disease), leprosy (as part of multidrug therapy), and Pneumocystis jirovecii pneumonia prophylaxis in immunocompromised patients (though trimethoprim-sulfamethoxazole is generally preferred). Its anti-inflammatory mechanism makes it suitable for a range of neutrophilic dermatoses.
Dosage and direction
For dermatitis herpetiformis, the initial adult dosage is typically 50 mg daily, which may be increased to 100–300 mg daily based on clinical response, often in divided doses. Maintenance doses are usually the lowest effective amount, often between 50–100 mg daily. For acne vulgaris, the common dosage is 50–100 mg daily. Dapsone topical gel (5% or 7.5%) is applied twice daily to affected areas. Administration with food may minimize gastrointestinal upset. Regular monitoring of complete blood count (CBC) and liver function tests is recommended, especially during the initial months of therapy. Dosage adjustments are necessary in patients with renal or hepatic impairment.
Precautions
Patients should be screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency prior to initiation due to the risk of hemolytic anemia. Baseline CBC, liver function tests, and renal function should be obtained. Use with caution in patients with cardiopulmonary disease, as dapsone can cause methemoglobinemia, particularly at higher doses. Monitor for signs of peripheral neuropathy, especially with long-term use. Pregnancy Category C: use only if potential benefit justifies potential risk to the fetus. Caution in lactating women. Avoid in patients with severe anemia or hypersensitivity to sulfonamides.
Contraindications
Dapsone is contraindicated in patients with known hypersensitivity to dapsone or other sulfone drugs. It is also contraindicated in patients with severe G6PD deficiency due to high risk of severe hemolysis. Use is prohibited in those with history of dapsone-induced agranulocytosis, aplastic anemia, or other severe blood dyscrasias. Concomitant use with trimethoprim-sulfamethoxazole is generally contraindicated due to increased risk of adverse hematological effects.
Possible side effect
Common side effects include headache, nausea, vomiting, and dizziness. Hematological effects may include hemolytic anemia (especially in G6PD-deficient individuals), methemoglobinemia, agranulocytosis, and leukopenia. Dermatological reactions such as rash, photosensitivity, and exfoliative dermatitis may occur. Less frequently, peripheral neuropathy, hepatitis, insomnia, and psychosis have been reported. Most side effects are dose-dependent and reversible upon discontinuation or dose reduction.
Drug interaction
Dapsone may interact with probenecid, increasing dapsone levels. Rifampin decreases dapsone levels by inducing hepatic metabolism. Concurrent use with trimethoprim increases the risk of hematological toxicity. Didanosine may reduce absorption of dapsone. Drugs that also cause methemoglobinemia (e.g., nitrates, local anesthetics) may have additive effects. Methotrexate and other myelosuppressive agents may enhance hematological toxicity. Monitor patients closely when used with these medications.
Missed dose
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, the missed dose should be skipped and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended. Consistent daily administration is important for maintaining therapeutic effect, particularly in chronic conditions.
Overdose
Symptoms of overdose may include nausea, vomiting, hyperexcitability, seizures, and severe methemoglobinemia (evidenced by cyanosis, hypoxia). Hemolytic anemia may be exacerbated. Management is supportive and includes gastric lavage if presented early, administration of activated charcoal, and methylene blue for methemoglobinemia (1–2 mg/kg IV slowly). Hemodialysis is not effective due to high protein binding. Symptomatic treatment for seizures and close monitoring of hematological parameters are essential.
Storage
Store at room temperature (20–25°C or 68–77°F), in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Do not store in bathrooms or near sinks. For topical formulations, ensure the tube or container is tightly closed when not in use.
Disclaimer
This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations and before starting or changing any medication regimen. Dosage and indications may vary based on individual patient factors and latest clinical guidelines.
Reviews
“Dapsone has been transformative for my dermatitis herpetiformis. Within weeks, the itching and blisters reduced significantly. Required regular blood monitoring, but well worth it.” – Patient, 44
“As a dermatologist, I find dapsone invaluable for stubborn inflammatory acne. It offers a different mechanism than antibiotics, often effective when others fail. Monitoring is key.” – Dr. A. Smith, MD
“Effective but requires vigilance for side effects. I experienced mild nausea initially, but it subsided. My acne cleared up remarkably after three months of use.” – Patient, 29