Crestor: Advanced LDL Cholesterol Reduction Therapy
| Product dosage: 10mg | |||
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| Product dosage: 20mg | |||
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| Product dosage: 5mg | |||
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Synonyms | |||
Similar products
Crestor (rosuvastatin calcium) is a prescription medication classified as a statin, specifically designed to manage high cholesterol and related lipid disorders. It functions by inhibiting HMG-CoA reductase, a key enzyme in the liver responsible for cholesterol production. Clinically proven to significantly lower low-density lipoprotein (LDL) cholesterol and triglycerides while raising high-density lipoprotein (HDL) cholesterol, Crestor plays a critical role in comprehensive cardiovascular risk reduction strategies. It is indicated for use in appropriate adult patients, often alongside diet and exercise, to reduce the risk of cardiovascular events.
Features
- Active ingredient: Rosuvastatin calcium
- Available in tablet strengths: 5 mg, 10 mg, 20 mg, 40 mg
- Administration: Oral, once daily
- FDA-approved for primary hyperlipidemia, mixed dyslipidemia, and hypertriglyceridemia
- Also indicated to slow atherosclerosis progression and reduce cardiovascular event risk in selected patients
- Manufactured under stringent quality control standards
Benefits
- Significantly reduces LDL (“bad”) cholesterol levels
- Lowers triglyceride concentrations in the bloodstream
- Increases HDL (“good”) cholesterol
- Reduces risk of heart attack, stroke, and arterial revascularization procedures
- Slows progression of atherosclerosis in coronary arteries
- May reduce C-reactive protein (CRP), a marker of inflammation associated with cardiovascular risk
Common use
Crestor is primarily prescribed for the management of dyslipidemias in adult patients. It is commonly used to treat primary hyperlipidemia and mixed dyslipidemia when response to diet and other non-pharmacological measures has been inadequate. Additionally, Crestor is indicated for patients with hypertriglyceridemia and to increase HDL-C in patients with primary hypoalphalipoproteinemia. Beyond lipid management, it is prescribed for atherosclerosis slowing and cardiovascular risk reduction in appropriate patient populations without clinically evident coronary heart disease but with increased risk factors.
Dosage and direction
The recommended starting dose is 10 mg or 20 mg orally once daily, with or without food. For patients requiring aggressive LDL-C reduction (>45%), a 20 mg starting dose may be considered. The 40 mg dose is reserved for patients who do not achieve goal LDL-C with 20 mg and should only be used after medical assessment. Dosage should be individualized according to baseline LDL-C levels, the goal of therapy, and patient response. Asian patients may require lower starting doses due to increased systemic exposure. Regular lipid levels should be monitored 2-4 weeks after initiation or titration.
Precautions
Patients should be advised to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by fever or malaise. Liver function tests should be performed before initiation and as clinically indicated thereafter. Blood glucose levels should be monitored as statins may increase HbA1c and fasting serum glucose levels. Use with caution in patients with predisposing factors for rhabdomyolysis, including renal impairment, advanced age, and uncontrolled hypothyroidism. Patients should avoid excessive alcohol consumption while taking Crestor.
Contraindications
Crestor is contraindicated in patients with active liver disease, including unexplained persistent elevations of hepatic transaminases. It is contraindicated in pregnancy and breastfeeding due to potential fetal harm and excretion in human milk. Concomitant use with cyclosporine is prohibited. Hypersensitivity to any component of this medication constitutes a contraindication. The 40 mg dose is contraindicated in patients with predisposing factors for myopathy/rhabdomyolysis, including Asian patients, severe renal impairment, and concomitant use with certain other medications.
Possible side effect
Common adverse reactions (≥2%) include headache, myalgia, abdominal pain, nausea, and constipation. Less frequent but clinically important side effects may include:
- Myopathy and rhabdomyolysis with acute renal failure
- Increased liver transaminases
- Memory loss and confusion
- Increased HbA1c and fasting serum glucose levels
- Rare hypersensitivity reactions including angioedema
- Proteinuria, typically transient and not indicative of renal disease
Drug interaction
Significant interactions occur with:
- Cyclosporine: Contraindicated (increases rosuvastatin exposure 7-fold)
- Gemfibrozil: Avoid combination (increases rosuvastatin exposure 2-fold)
- Antacids: Decrease rosuvastatin absorption; administer at least 2 hours apart
- Warfarin: May increase INR; monitor coagulation parameters
- Protease inhibitors: Particularly combination HIV therapy, may increase statin exposure
- Niacin: May increase risk of myopathy
Missed dose
If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. Patients should not take double or extra doses to make up for a missed dose. Consistency in daily administration helps maintain stable cholesterol-lowering effects.
Overdose
There is no specific antidote for rosuvastatin overdose. In case of suspected overdose, symptomatic and supportive measures should be instituted. Liver function and CK levels should be monitored. The patient should be observed for signs and symptoms of myopathy and renal failure. Hemodialysis is unlikely to enhance clearance as rosuvastatin is extensively protein-bound. Medical attention should be sought immediately for any suspected overdose situation.
Storage
Store at room temperature (20-25°C or 68-77°F) with excursions permitted between 15-30°C (59-86°F). Keep in the original container with the lid tightly closed to protect from moisture and light. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Proper disposal of unused medication should follow local regulations, typically through medication take-back programs.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Crestor is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Individual results may vary. Patients should not initiate, discontinue, or change dosage without consulting their physician. The full prescribing information should be consulted before initiating therapy.
Reviews
Clinical trials demonstrate Crestor’s efficacy in significant LDL-C reduction, with studies showing 46-63% decreases depending on dose. The JUPITER trial particularly highlighted its role in primary prevention, showing a 44% reduction in major cardiovascular events in patients with elevated CRP. Many physicians report satisfactory patient outcomes with appropriate monitoring. Some patients report mild side effects, primarily muscle-related, which often resolve with dose adjustment. Overall, Crestor maintains a favorable risk-benefit profile when used according to prescribing guidelines in appropriate patient populations.