Combimist L Inhaler: Dual-Action Relief for Asthma and COPD

Combimist L Inhaler

Product dosage: 50mcg+20mcg
Package (num)	Per inhaler	Price	Buy
2	$30.12	$60.24 (0%)	🛒 Add to cart
3	$27.11 Best per inhaler	$90.36 $81.32 (10%)	🛒 Add to cart

The Combimist L Inhaler is a pressurized metered-dose inhaler (pMDI) designed for the maintenance treatment of reversible obstructive airways diseases, including asthma and chronic obstructive pulmonary disease (COPD). It combines two active ingredients—Levosalbutamol and Ipratropium Bromide—in a single device, offering both rapid bronchodilation and sustained airway control. This fixed-dose combination simplifies treatment regimens, enhances patient adherence, and provides comprehensive management of bronchospasm. It is indicated for patients who require regular bronchodilator therapy and have not achieved adequate control with a single agent.

Features

Contains Levosalbutamol (the active R-enantiomer of Salbutamol) 50 mcg and Ipratropium Bromide 20 mcg per puff
Delivered via a hydrofluoroalkane (HFA) propellant, which is ozone-friendly
Each canister provides 200 metered inhalations
Equipped with a dose counter to track remaining medication
Designed with an ergonomic mouthpiece for ease of use
Requires minimal priming—shake well before initial use and if not used for more than 7 days

Benefits

Provides rapid and prolonged bronchodilation by targeting both beta-2 adrenergic receptors and muscarinic cholinergic receptors
Reduces the frequency and severity of asthma and COPD exacerbations
Simplifies medication routine by combining two therapies in one inhaler
Improves lung function parameters such as FEV1 and peak expiratory flow
Enhances overall quality of life by reducing breathlessness and increasing exercise tolerance
Minimizes the need for rescue medication through effective maintenance control

Common use

Combimist L Inhaler is commonly prescribed for the maintenance treatment of bronchospasm associated with obstructive airway diseases. It is especially beneficial for patients with moderate to severe asthma or COPD who require dual bronchodilator therapy. It is not intended for immediate relief of acute bronchospasm; a separate short-acting beta-agonist inhaler should be used for rescue purposes. Regular use helps in controlling symptoms such as wheezing, shortness of breath, and chest tightness.

Dosage and direction

The usual recommended dose for adults and adolescents aged 12 years and older is two puffs, taken two times daily (morning and evening). In some cases, healthcare providers may adjust the dosage to a maximum of two puffs four times daily, based on symptom severity and individual response. Always shake the inhaler well before each use. Exhale fully, place the mouthpiece between the lips, and inhale deeply and slowly while pressing the canister. Hold your breath for about 10 seconds, then exhale slowly. Wait at least 30 seconds before taking a second puff, if prescribed. Rinse the mouth with water after each use to reduce the risk of oral thrush.

Precautions

Not for use in children under 12 years of age unless specifically advised by a physician.
Use with caution in patients with cardiovascular disorders, including hypertension, arrhythmias, or ischemic heart disease.
Monitor for signs of worsening bronchospasm; paradoxical bronchospasm may occur and require discontinuation.
May cause narrow-angle glaucoma or urinary retention in susceptible individuals; advise patients to report eye pain or blurred vision.
Avoid contact with eyes; accidental exposure may cause pupil dilation and visual disturbances.
Not recommended during pregnancy or lactation unless potential benefits outweigh risks.
Use cautiously in patients with diabetes, as beta-agonists may increase blood glucose levels.
Regular monitoring of pulmonary function and symptom control is advised.

Contraindications

Hypersensitivity to Levosalbutamol, Ipratropium Bromide, atropine, or any component of the formulation.
History of tachyarrhythmias or severe cardiac disease.
Untreated or uncontrolled narrow-angle glaucoma.
Bladder neck obstruction or prostatic hyperplasia causing significant urinary retention.
Not indicated for the initial treatment of acute episodes of bronchospasm.

Possible side effect

Common side effects may include:

Headache
Dry mouth
Tremor
Cough
Throat irritation
Nausea
Palpitations
Dizziness

Less common but serious side effects requiring medical attention:

Paradoxical bronchospasm (wheezing immediately after use)
Tachycardia or other cardiac arrhythmias
Increased intraocular pressure (glaucoma)
Hypokalemia
Allergic reactions such as rash, urticaria, or angioedema

Drug interaction

Beta-blockers (e.g., propranolol) may antagonize the effects of Levosalbutamol and cause bronchospasm.
Other sympathomimetic agents may potentiate cardiovascular effects.
Diuretics or corticosteroids may increase the risk of hypokalemia.
Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants may enhance the cardiovascular effects of beta-agonists.
Anticholinergic drugs (e.g., tiotropium) may increase the risk of side effects like dry mouth and urinary retention.
Xanthine derivatives (e.g., theophylline) may increase the risk of tachycardia and other stimulatory effects.

Missed dose

If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Overdose may manifest as exaggerated pharmacologic effects such as tachycardia, tremor, hypertension, hypokalemia, angina, and nausea. Anticholinergic symptoms like dry mouth, blurred vision, and urinary retention may also occur. Treatment is supportive and symptomatic; cardioselective beta-blockers may be considered in severe cases, but only under strict medical supervision due to the risk of inducing bronchospasm. Immediate medical attention is required.

Storage

Store at room temperature (15–30°C), away from direct heat and sunlight. Do not puncture or incinerate the canister, even when empty. Keep out of reach of children. The inhaler should be discarded after the labeled number of doses has been used or after the expiration date, whichever comes first.

Disclaimer

This information is intended for educational purposes only and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized medical guidance. Do not initiate or discontinue medication without consulting your physician.

Reviews

“After switching to Combimist L, my COPD symptoms are much better controlled. I only need my rescue inhaler occasionally now.” – Maria K., 64

“Effective and convenient. The dose counter is a helpful feature to ensure I don’t run out unexpectedly.” – James L., 52

“My asthma has been more stable since starting this inhaler. I experience fewer nighttime symptoms and can be more active.” – Sophie T., 38

“Initially experienced a mild tremor, but it subsided after a week. Worth it for the improved breathing.” – Robert P., 59