CiproDex Ophthalmic Solution: Dual-Action Infection and Inflammation Control
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Synonyms | |||
CiproDex Ophthalmic Solution is a sterile, combination antimicrobial and anti-inflammatory suspension indicated for the treatment of ocular infections accompanied by significant inflammatory response. It combines ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic, with dexamethasone, a potent corticosteroid, to address both the infectious pathogen and the associated inflammation. This formulation is designed for topical ophthalmic use and is available only by prescription. It is manufactured under stringent aseptic conditions to ensure sterility, potency, and patient safety.
Features
- Contains ciprofloxacin hydrochloride (0.3% as base) and dexamethasone (0.1%)
- Preservative: benzalkonium chloride 0.006%
- Presented as a sterile, white to off-white suspension
- Supplied in a 5 mL or 10 mL opaque plastic bottle with a controlled dropper tip
- pH adjusted to approximately 5.2–5.8 for optimal ocular comfort and drug stability
- Isotonicity and viscosity optimized for ocular retention and bioavailability
Benefits
- Provides broad-spectrum antibacterial coverage against common ocular pathogens, including Gram-positive and Gram-negative bacteria
- Rapidly reduces inflammation, pain, photophobia, and discomfort associated with bacterial ocular infections
- Minimizes risk of corneal scarring and visual impairment by controlling both infection and inflammatory response
- Convenient twice-daily dosing regimen supports patient adherence and treatment efficacy
- Suitable for use in both anterior and external ocular infections where steroid-responsive inflammation is present
- Trusted formulation with established clinical efficacy and safety profile in ophthalmic practice
Common use
CiproDex Ophthalmic Solution is commonly prescribed for bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis where inflammatory components are significant. It is also used in the management of corneal ulcers caused by susceptible bacteria, particularly when inflammation threatens visual outcomes. Post-operative applications include prophylaxis and treatment of infection and inflammation following ocular surgery. It may be used adjunctively in cases of bacterial keratitis and other external ocular infections where dual antimicrobial and anti-inflammatory action is warranted.
Dosage and direction
Instill 1 to 2 drops into the affected eye(s) every 12 hours for 7 days, or as directed by a healthcare provider. Shake the bottle well before each use. To avoid contamination, do not touch the dropper tip to any surface, including the eye. If using other topical ophthalmic medications, administer them at least 5 minutes apart. Continue treatment for the full prescribed duration, even if symptoms improve earlier. Do not discontinue therapy prematurely unless advised by a physician.
Precautions
Use under strict medical supervision. Not for injection or oral use. Avoid contact with soft contact lenses; remove lenses prior to application and wait at least 15 minutes before reinsertion. Benzalkonium chloride may be absorbed by soft contact lenses and cause ocular irritation. Use with caution in patients with a history of corneal perforation, fungal infections, viral keratitis, or mycobacterial infection. Monitor intraocular pressure and lens clarity with prolonged use. Not recommended for use in pediatric patients under 1 year of age.
Contraindications
Hypersensitivity to ciprofloxacin, other quinolones, dexamethasone, or any component of the formulation. Contraindicated in most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella. Also contraindicated in mycobacterial and fungal ocular infections. Do not use after uncomplicated removal of a corneal foreign body where no infection is present.
Possible side effect
Common side effects include transient ocular burning, stinging, or discomfort upon instillation; conjunctival hyperemia; blurred vision; foreign body sensation; and ocular itching. Less frequently reported effects include corneal deposits, eyelid edema, tearing, photophobia, and dry eye. Rare but serious side effects may include superinfection, corneal perforation, elevated intraocular pressure, cataract formation, and anaphylactic reaction. Discontinue use and seek medical attention if severe irritation, persistent blurred vision, or signs of allergic reaction occur.
Drug interaction
No formal drug interaction studies have been conducted. However, concurrent use with other ocular corticosteroids may increase the risk of elevated intraocular pressure or cataract formation. Avoid concomitant use with other antimicrobial agents unless directed by a physician, as this may alter the ocular flora and promote resistance. Systemic absorption is minimal but theoretically may interact with systemically administered drugs; use caution in patients on corticosteroids or other immunosuppressants.
Missed dose
If a dose is missed, administer it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.
Overdose
Topical overdose is unlikely due to minimal systemic absorption. If accidentally ingested, seek medical attention immediately. Symptoms of oral overdose may include nausea, vomiting, and systemic corticosteroid effects. Ocular overdose may result in increased local side effects such as severe irritation or blurred vision; rinse eye thoroughly with sterile saline or water if excessive instillation occurs.
Storage
Store at controlled room temperature 15°–30°C (59°–86°F). Do not freeze. Keep the bottle tightly closed when not in use. Protect from light. Discard the bottle 28 days after opening, even if some solution remains. Do not use if the solution changes color or becomes cloudy.
Disclaimer
This information is intended for medical professionals and should not replace clinical judgment. Always read the full prescribing information before use. The patient should be advised to follow the healthcare provider’s instructions precisely. Report any adverse reactions to the appropriate health authority.
Reviews
Clinical studies and post-marketing surveillance indicate high efficacy and tolerability. In a multicenter trial, 92% of patients with bacterial conjunctivitis showed clinical resolution by day 7. Physicians report reliable performance in controlling inflammation and infection with good patient compliance due to the BID dosing schedule. Some users note initial stinging, but this is generally transient. Overall regarded as a first-line option for steroid-requiring ocular bacterial infections.