Calcort: Advanced Glucocorticoid Therapy for Severe Inflammation Control
| Product dosage: 6 mg | |||
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Synonyms | |||
Calcort (Deflazacort) is a second-generation glucocorticoid engineered to deliver potent anti-inflammatory and immunosuppressive effects with a potentially improved tolerability profile compared to traditional corticosteroids. It is specifically indicated for the management of chronic inflammatory and autoimmune conditions where sustained immunological modulation is required. By offering a balanced mechanism of action, Calcort helps clinicians achieve therapeutic goals while potentially mitigating some classic steroid-associated adverse effects, making it a valuable option in long-term treatment regimens.
Features
- Active ingredient: Deflazacort 6 mg and 30 mg tablets
- Glucocorticoid receptor agonist with anti-inflammatory and immunomodulatory properties
- Modified pharmacokinetic profile favoring once-daily dosing
- Available in scored tablets for accurate dose titration
- Manufactured under strict pharmaceutical compliance standards
Benefits
- Provides rapid and sustained control of inflammatory symptoms
- May offer a reduced incidence of certain steroid-related side effects such as fluid retention and hypertension
- Supports functional improvement in chronic autoimmune conditions
- Enables flexible dosing tailored to individual patient response and disease severity
- Facilitates long-term disease management with once-daily administration
- Helps reduce dependency on rescue medications and emergency interventions
Common use
Calcort is commonly prescribed for a range of inflammatory and immune-mediated disorders, including but not limited to rheumatoid arthritis, systemic lupus erythematosus, dermatological conditions such as severe psoriasis, and allergic states resistant to conventional treatments. It is also used in management protocols for certain hematological conditions and organ transplant-related immunosuppression. Its use is generally reserved for cases where first-line treatments have proven inadequate or intolerable.
Dosage and direction
Dosage must be individualized based on disease severity, patient response, and concomitant therapies. For most adults, the initial dose ranges from 6 mg to 90 mg daily, administered once per day, preferably in the morning with food to minimize gastrointestinal discomfort. Dosage should be titrated to the lowest effective level once clinical control is achieved. Long-term therapy requires gradual tapering to avoid adrenal insufficiency. Pediatric dosing is weight-based and must be carefully supervised by a specialist.
Precautions
Patients should be monitored for hyperglycemia, hypertension, electrolyte imbalances, and changes in weight. Bone density assessments are recommended during prolonged therapy. Use with caution in patients with a history of peptic ulcer disease, psychiatric disorders, or latent infections. Immunizations with live vaccines should be avoided during treatment. Ophthalmological examinations are advised for patients on extended courses due to risk of cataracts and glaucoma.
Contraindications
Calcort is contraindicated in patients with systemic fungal infections, known hypersensitivity to Deflazacort or any excipients in the formulation, and those with untreated active bacterial or viral infections. It should not be used in patients with recent live vaccine administration. Avoid use in patients with uncontrolled severe hypertension or acute psychosis.
Possible side effect
Common side effects may include gastrointestinal discomfort, insomnia, mood changes, increased appetite, and weight gain. Less frequently, patients may experience elevated blood pressure, glucose intolerance, fluid retention, or skin thinning. Long-term use can lead to more serious effects such as osteoporosis, adrenal suppression, cataracts, and increased susceptibility to infections. Any unusual symptoms should be reported immediately.
Drug interaction
Calcort may interact with anticoagulants, antidiabetic agents, anticonvulsants (e.g., phenytoin), and drugs metabolized via CYP3A4. Concurrent use with NSAIDs increases gastrointestinal risk. It may reduce the efficacy of vaccines and enhance hypokalemia when used with diuretics. Always review the full medication list before initiation.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose. Consistent daily intake is important to maintain stable therapeutic levels, especially in tapering regimens.
Overdose
Acute overdose may exacerbate typical side effects, such as severe hyperglycemia, hypertension, or psychiatric symptoms. There is no specific antidote; management is supportive and symptomatic. Gastric lavage may be considered if ingestion was recent. Medical supervision is required.
Storage
Store at room temperature (15–30°C) in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and individualized dosing. Do not initiate or discontinue therapy without medical supervision.
Reviews
Clinical studies and post-marketing surveillance indicate that Calcort is effective in controlling inflammation with a manageable side effect profile for many patients. Experts appreciate its utility in steroid-dependent cases where a more favorable benefit-risk ratio is desired. Patient-reported outcomes often highlight improved quality of life and functional capacity, though experiences may vary based on individual factors and underlying conditions.