Bactroban Ointment 5g: Targeted Topical Antibiotic for Skin Infection Resolution
| Product dosage: 20mg | |||
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Synonyms | |||
Bactroban Ointment 5g contains mupirocin 2% w/w as the active pharmaceutical ingredient, formulated in a polyethylene glycol base. This prescription topical antibacterial is specifically indicated for the treatment of secondary infected traumatic skin lesions and impetigo caused by susceptible strains of Staphylococcus aureus and Streptococcus pyogenes. Its unique mechanism of action inhibits bacterial protein synthesis, providing targeted antimicrobial activity while minimizing systemic exposure. Clinical studies demonstrate high efficacy rates in eradicating pathogenic bacteria when used appropriately under medical supervision.
Features
- Contains mupirocin 2% w/w (20 mg/g) as the active ingredient
- Available in 5g tube with precise dosage calibration
- White to off-white ointment in polyethylene glycol base
- Water-miscible formulation that penetrates skin effectively
- Specifically bactericidal against Gram-positive organisms
- Stable at room temperature with two-year shelf life
- Minimal systemic absorption with localised action
- Prescription-only medication requiring professional diagnosis
Benefits
- Rapidly eliminates susceptible bacterial pathogens from infected skin sites
- Reduces bacterial load within 24-48 hours of initiation
- Helps prevent progression of localised infections to systemic involvement
- Minimises risk of infection transmission to other body sites or contacts
- Supports natural healing processes by controlling secondary infection
- Convenient topical application avoids gastrointestinal side effects associated with oral antibiotics
Common use
Bactroban Ointment is primarily prescribed for the topical treatment of impetigo, a contagious superficial skin infection characterized by honey-colored crusted lesions, typically caused by Staphylococcus aureus or Streptococcus pyogenes. It is also indicated for secondary infected traumatic skin lesions where bacterial contamination has occurred, such as minor cuts, abrasions, or sutured wounds that show signs of clinical infection including erythema, edema, purulent discharge, or increasing pain. Dermatologists may also employ it for decolonization of S. aureus carriers in specific clinical scenarios, particularly when dealing with recurrent skin infections or preoperative preparation. The ointment is not indicated for fungal, viral, or parasitic infections, and should only be used when bacterial etiology has been confirmed or strongly suspected.
Dosage and direction
Apply a small amount of Bactroban Ointment to the affected area three times daily (approximately every 8 hours). The area may be covered with a gauze dressing if desired, particularly for lesions prone to contamination or clothing contact. Before application, gently cleanse the affected area with appropriate antiseptic solution and pat dry. Use just enough ointment to cover the affected area with a thin film; excessive application does not enhance efficacy and may increase local adverse effects. Treatment duration typically ranges from 7 to 10 days for most indications, though physicians may adjust based on clinical response. Complete the full course of treatment even if symptoms improve earlier to prevent recurrence and development of resistance. Wash hands thoroughly before and after application to prevent cross-contamination.
Precautions
Use Bactroban Ointment only as directed by a healthcare professional and complete the full prescribed course. Avoid contact with eyes, nostrils, mouth, or other mucous membranes as it may cause irritation; if accidental contact occurs, rinse thoroughly with water. Discontinue use and consult your physician if irritation, severe itching, or rash develops. This medication is for external use only and should not be applied to large body surface areas, especially if skin barrier is compromised, due to potential for systemic absorption. Use with caution in patients with moderate to severe renal impairment as polyethylene glycol excipient may be absorbed systemically. Prolonged use may result in overgrowth of non-susceptible organisms including fungi; monitor for signs of superinfection. Not recommended for use in children under 3 months of age due to limited safety data.
Contraindications
Bactroban Ointment is contraindicated in patients with known hypersensitivity to mupirocin or any component of the formulation, including polyethylene glycol. Should not be used for the treatment of non-bacterial skin conditions such as fungal infections, viral infections (including herpes simplex), acne, or parasitic infestations. Contraindicated in patients with extensive burns or severe skin damage where significant systemic absorption might occur. Not recommended for use in the external ear canal if the eardrum is perforated due to potential for ototoxicity. Avoid use in patients with history of allergic contact dermatitis to topical antibiotics, particularly those with cross-sensitivity to other antibiotic classes.
Possible side effect
Most common adverse reactions (occurring in 1-3% of patients) include application site reactions such as burning, stinging, or pain. Less frequently reported effects include itching (pruritus), erythema, dryness, and contact dermatitis. Rare side effects (<1% incidence) include nausea, headache, and skin tenderness. Systemic reactions are uncommon due to minimal absorption but may include allergic reactions characterized by angioedema, urticaria, or bronchospasm in hypersensitive individuals. Superinfection with non-susceptible organisms including methicillin-resistant staphylococci, Gram-negative bacteria, or fungi may occur with prolonged use. Cases of generalized allergic reactions including anaphylaxis have been reported rarely. Discontinue use and seek medical attention if severe reactions occur.
Drug interaction
Formal drug interaction studies have not been conducted with topical mupirocin due to minimal systemic absorption. However, concurrent use with other topical products applied to the same area may alter absorption characteristics or cause physical/chemical interactions. Avoid simultaneous application with other topical antibiotics, corticosteroids, or acne medications unless specifically directed by a physician. The polyethylene glycol base may interact with certain dressing materials or other topical agents. No clinically significant interactions with systemically administered drugs have been reported, though caution is advised when using with other potentially nephrotoxic agents in patients with renal impairment due to possible polyethylene glycol absorption.
Missed dose
If a dose is missed, apply it as soon as remembered unless it is almost time for the next scheduled application. Do not double the dose to make up for a missed application. Maintain the regular three-times-daily schedule, ensuring approximately 8 hours between applications. If multiple doses are missed or treatment interruption exceeds 24 hours, consult your healthcare provider for guidance on whether to extend the treatment duration. Consistent application is important for maintaining effective antibiotic concentrations at the infection site and preventing development of resistance.
Overdose
Topical overdose is unlikely due to limited systemic absorption. However, excessive application over large body surface areas, particularly on compromised skin, might lead to systemic effects of the polyethylene glycol base including osmotic diarrhea, metabolic acidosis, and renal impairment in susceptible individuals. In case of accidental ingestion, seek medical attention immediately; symptoms may include gastrointestinal irritation, nausea, and diarrhea. There is no specific antidote; treatment should be symptomatic and supportive. For topical overdose, cleanse the area thoroughly to remove excess medication. Hemodialysis may be effective for removing polyethylene glycol in cases of significant systemic absorption.
Storage
Store Bactroban Ointment at controlled room temperature between 15-30°C (59-86°F). Do not freeze. Keep the tube tightly closed when not in use to prevent contamination and moisture absorption. Protect from excessive heat and direct sunlight. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Discard any medication that has changed color, consistency, or shows signs of separation. Do not transfer the ointment to other containers as this may compromise sterility and stability.
Disclaimer
This information is provided for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment recommendations. Individual response to medication may vary based on specific health conditions, age, and other factors. The prescribing physician should be informed of all current medications and health conditions before using this product. Proper diagnosis of the infection type and susceptibility testing are essential for appropriate antibiotic selection. Resistance patterns may vary geographically; local epidemiological data should guide therapy decisions.
Reviews
Clinical studies demonstrate Bactroban Ointment achieves clinical cure rates of 85-95% in impetigo when caused by susceptible organisms. Dermatologists consistently report high satisfaction with its efficacy in treating localized skin infections, particularly noting its rapid onset of action and favorable safety profile compared to systemic antibiotics. Patients appreciate the convenience of topical application and minimal side effects. Some reviews note that effectiveness diminishes when infections are caused by resistant strains or mixed organisms. Healthcare professionals emphasize the importance of proper diagnosis before initiation to ensure appropriate use and prevent antibiotic resistance. Long-term clinical experience spanning decades supports its position as a first-line topical antibiotic for specific Gram-positive skin infections.