Alli: Clinically Proven Weight Loss Aid for Adults
| Product dosage: 60mg | |||
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Synonyms | |||
Alli (orlistat 60 mg) is the only FDA-approved over-the-counter weight loss aid designed for use alongside a reduced-calorie, low-fat diet. It works locally in the digestive system to prevent the absorption of about 25% of dietary fat. By blocking fat enzymes, it supports a calorie deficit, making it easier to achieve and sustain weight loss. This non-systemic medication is intended for adults with a body mass index (BMI) of 25 or higher who are committed to a structured weight management plan.
Features
- Contains 60 mg of orlistat per capsule
- Non-prescription strength; the only FDA-approved OTC weight loss aid
- Works in the digestive tract without affecting the central nervous system
- Prevents absorption of approximately 25% of dietary fat
- Gluten-free formulation
- Packaged with a tailored support plan and dietary guidance
Benefits
- Supports clinically significant weight loss when combined with diet and exercise
- Encourages adherence to a lower-fat dietary regimen due to its mechanism of action
- Provides a non-stimulant alternative to other weight management supplements
- Helps establish long-term healthy eating habits through feedback mechanism
- Can improve metabolic parameters such as cholesterol levels in some individuals
- Empowers users with an evidence-based tool as part of a comprehensive weight management strategy
Common use
Alli is commonly used by adults aged 18 and older with an initial body mass index (BMI) of 25 or greater as an adjunct to a reduced-calorie, low-fat diet. It is suitable for individuals seeking a non-habit-forming, pharmacologic option to support weight loss efforts. Typical users include those who have struggled to lose weight through diet and exercise alone and are looking for an additional tool to help create a sustainable calorie deficit. It is often incorporated into weight management plans under occasional healthcare supervision, particularly for individuals with obesity-related health risks.
Dosage and direction
Take one 60 mg capsule with water immediately before, during, or up to one hour after each main meal that contains fat. Do not exceed three capsules per day. If a meal is missed or contains no fat, the dose of Alli should be omitted. A daily multivitamin containing fat-soluble vitamins (A, D, E, K) should be taken once per day at bedtime or at least 2 hours before or after taking Alli to ensure adequate nutrient absorption. It is important to follow a nutritionally balanced, reduced-calorie diet averaging 30% of calories from fat while using this medication.
Precautions
- Not intended for use by individuals with a BMI below 25.
- Should not be used by anyone with chronic malabsorption syndrome or cholestasis.
- Use with caution in patients with a history of hyperoxaluria or calcium oxalate nephrolithiasis.
- May reduce the absorption of fat-soluble vitamins and beta-carotene; supplementation is recommended.
- Not suitable for use during pregnancy or breastfeeding.
- Patients with diabetes may require adjustment of diabetic medications as weight loss occurs.
- May cause gastrointestinal effects, especially if meals contain more than 30% fat.
Contraindications
- Hypersensitivity to orlistat or any component of the formulation.
- Organ transplant recipients due to potential interaction with immunosuppressive therapy like cyclosporine.
- Patients with reduced gallbladder function or history of pancreatitis.
- Individuals with anorexia nervosa or bulimia.
- Concurrent use with acarbose or other weight loss products.
- Patients taking warfarin or other anticoagulants should use only under close medical supervision due to possible changes in coagulation parameters.
Possible side effects
Common side effects are largely gastrointestinal and related to fat malabsorption. These may include:
- Oily spotting
- Flatus with discharge
- Fecal urgency
- Fatty or oily stool
- Oily evacuation
- Increased defecation
- Fecal incontinence
These effects are generally transient and may diminish over time as dietary fat intake is controlled. Less common side effects can include abdominal discomfort or pain, nausea, infectious diarrhea, and headache. Rare cases of severe liver injury have been reported with orlistat use, though causality has not been firmly established.
Drug interaction
Alli may interact with several medications:
- Cyclosporine: Administer at least 2 hours before or after Alli.
- Warfarin: Monitor INR regularly as weight loss and reduced vitamin K absorption may affect coagulation.
- Levothyroxine: Administer at least 4 hours apart to avoid impaired absorption.
- Antiepileptic drugs (e.g., valproate, lamotrigine): Monitor levels as weight loss may affect dosage requirements.
- Amiodarone: Potential for reduced absorption.
- Antiretroviral medications, particularly HIV protease inhibitors: may require dosage adjustment or separation of administration.
- Fat-soluble vitamin supplements should be taken at least 2 hours apart from Alli.
Missed dose
If you miss a dose, take it with your next fat-containing meal. However, if it is almost time for your next meal, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. Consistency with meals containing fat is important for both efficacy and managing gastrointestinal side effects.
Overdose
There have been no reports of serious adverse events from overdose. Single doses of 800 mg orlistat and multiple doses up to 400 mg three times daily for 15 days have been studied without significant adverse effects. In case of suspected overdose, medical attention should be sought. Treatment should be symptomatic and supportive. Given its local action in the GI tract, systemic toxicity is unlikely, but monitoring for severe gastrointestinal effects is recommended.
Storage
Store at room temperature between 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C to 30°C (59°F to 86°F). Keep the bottle tightly closed and stored in its original container to protect from moisture and light. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Alli should be used as part of a comprehensive weight loss program including reduced-calorie diet and regular physical activity. Read and follow all label instructions before use. Consult with a healthcare professional before starting any weight loss program, especially if you have underlying medical conditions or are taking other medications. Not for use by those under 18 years of age.
Reviews
Clinical studies demonstrate that individuals using orlistat 60 mg three times daily along with a reduced-calorie diet lose significantly more weight than those using diet alone. In a 6-month study, 40% of patients achieved ≥5% weight loss compared to 24% with placebo. Many users report successful weight loss when adhering strictly to dietary recommendations, though gastrointestinal side effects are frequently mentioned, particularly during the initiation phase. Long-term users often note that the medication provides helpful feedback for maintaining lower fat intake. Healthcare providers generally recommend Alli as part of a structured weight management plan for appropriate candidates.