Allegra: Advanced Relief for Seasonal Allergy Symptoms
| Product dosage: 120mg | |||
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| Product dosage: 180mg | |||
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Synonyms
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Allegra (fexofenadine hydrochloride) is a leading non-drowsy antihistamine specifically formulated to provide comprehensive relief from seasonal allergic rhinitis symptoms. Developed through extensive clinical research, this second-generation H1-receptor antagonist offers targeted action with minimal central nervous system penetration, making it a preferred choice among healthcare professionals and patients seeking effective, 24-hour symptom control without sedation. Its well-established efficacy and favorable safety profile have positioned it as a first-line therapy in allergy management protocols worldwide.
Features
- Contains fexofenadine hydrochloride 60 mg or 180 mg as active pharmaceutical ingredient
- Rapid-acting formula with onset of action within one hour
- 24-hour sustained symptom relief with single daily dosing
- Non-drowsy formulation with minimal sedative effects
- Available in tablet, orally disintegrating tablet, and oral suspension formulations
- No requirement for dose adjustment in hepatic impairment
- Pregnancy Category C classification
- Manufactured under strict pharmaceutical quality control standards
Benefits
- Provides comprehensive relief from sneezing, rhinorrhea, itchy nose/palate/throat, and itchy/watery/red eyes
- Maintains alertness and cognitive function without causing significant drowsiness
- Enables consistent daily activities and occupational performance without impairment
- Offers convenient once-daily dosing for improved medication adherence
- Reduces nasal congestion through effective histamine blockade
- Suitable for long-term management of chronic allergic conditions
Common use
Allegra is primarily indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. These symptoms include sneezing, rhinorrhea, itchy nose/palate/throat, and itchy/watery/red eyes. It is also approved for the treatment of chronic idiopathic urticaria (hives) in patients 6 months and older. Healthcare providers may prescribe Allegra off-label for other histamine-mediated conditions based on clinical judgment and emerging evidence.
Dosage and direction
For seasonal allergic rhinitis in adults and children 12 years and older: 60 mg twice daily or 180 mg once daily. For children 6-11 years: 30 mg twice daily. For chronic idiopathic urticaria in adults and children 12 years and older: 60 mg twice daily. For children 6-11 years: 30 mg twice daily. For children 2-5 years with chronic idiopathic urticaria: 15 mg twice daily. For children 6 months to 2 years: 15 mg twice daily. Administer with water on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with fruit juices (particularly apple, orange, or grapefruit) as they may decrease absorption.
Precautions
Patients with renal impairment require dosage adjustment; for creatinine clearance less than 80 mL/min, reduce dose to 60 mg once daily. Use with caution in elderly patients, particularly those with age-related renal function decline. While Allegra demonstrates minimal sedative effects, patients should exercise caution when operating machinery or performing hazardous activities until they determine their individual response. Pregnant women should use only if clearly needed, and breastfeeding mothers should consult healthcare providers as fexofenadine is excreted in human milk.
Contraindications
Hypersensitivity to fexofenadine hydrochloride or any component of the formulation. Concomitant use with aluminum and magnesium-containing antacids (separate administration by at least 2 hours). Patients with severe renal impairment (creatinine clearance less than 30 mL/min) without appropriate dosage adjustment. Use in children under 6 months of age for any indication.
Possible side effects
Most common adverse reactions (≥2% and greater than placebo) include headache (10.6%), upper respiratory tract infection (3.2%), back pain (2.9%), and dysmenorrhea (2.5%). Less frequently reported effects include nausea (1.6%), dizziness (1.3%), and drowsiness (1.3%). Rare cases of hypersensitivity reactions including rash, urticaria, pruritus, and angioedema have been reported. Post-marketing surveillance has identified isolated cases of tachycardia, palpitations, and insomnia, though causal relationship remains uncertain.
Drug interaction
Allegra has demonstrated minimal metabolism by cytochrome P450 enzymes, resulting in fewer drug interactions compared to first-generation antihistamines. However, concomitant administration with erythromycin or ketoconazole may increase fexofenadine plasma concentrations by 60-70%. Antacids containing aluminum and magnesium reduce fexofenadine absorption by approximately 30-40%. Fruit juices (particularly apple, orange, and grapefruit) may decrease bioavailability by inhibiting OATP transport systems. Monitor patients closely when co-administering with P-glycoprotein inhibitors.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next scheduled dose. Do not double the dose to make up for the missed dose. Resume regular dosing schedule. For once-daily formulations, if remembered within 12 hours of missed dose, take immediately; if more than 12 hours have passed, skip the missed dose and resume normal schedule.
Overdose
Cases of overdose have reported dizziness, drowsiness, and dry mouth. In clinical trials, doses up to 800 mg once daily (approximately 4.4 times the maximum recommended daily dose) for two weeks showed no significant adverse effects. Standard supportive measures are recommended, including gastric lavage if presented soon after ingestion. Hemodialysis does not effectively remove fexofenadine from plasma due to high protein binding and extensive tissue distribution.
Storage
Store at controlled room temperature 20-25°C (68-77°F). Keep in original container with lid tightly closed. Protect from excessive moisture and light. Keep out of reach of children. Do not use if blister packaging is compromised or tablets show signs of deterioration. Discard any unused medication after expiration date printed on packaging.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual responses to medication may vary. Consult with a qualified healthcare professional before starting any new medication or making changes to existing treatment regimens. Always follow the specific dosing instructions provided by your prescribing physician and read the complete product labeling before use.
Reviews
Clinical studies demonstrate Allegra’s efficacy with 60-70% of patients experiencing significant symptom improvement compared to placebo. In a 2-week study involving 861 patients with seasonal allergic rhinitis, Allegra 180 mg once daily provided superior relief of total symptom scores (p<0.001) with incidence of drowsiness similar to placebo (1.3% vs 0.9%). Patient satisfaction surveys indicate high rates of continued use due to effectiveness and lack of sedative effects. Healthcare providers consistently rate Allegra as a first-line choice for allergic rhinitis management based on its favorable risk-benefit profile.