Acticin: Effective Permethrin-Based Scabies and Lice Treatment
Acticin is a topical prescription medication containing permethrin 5% as its active ingredient, formulated specifically for the eradication of Sarcoptes scabiei (scabies mites) and Pediculus humanus capitis (head lice) infestations. It belongs to the pyrethroid class of insecticides, which work by disrupting the nervous system of parasites upon contact, leading to paralysis and death. This cream formulation is designed for precise, localized application, offering a potent and targeted approach to parasitic skin conditions. Its efficacy is well-documented in clinical settings, making it a first-line treatment recommended by dermatologists and pediatricians worldwide for patients aged two months and older.
Features
- Contains 5% permethrin, a synthetic pyrethroid insecticide
- Topical cream formulation for direct skin application
- Clinically proven ovicidal (egg-killing) and pediculicidal (lice-killing) activity
- Single-application treatment course for most cases of scabies
- Minimal systemic absorption when used as directed
- Available in 60g tubes for full-body coverage
Benefits
- Provides rapid relief from intense itching and skin irritation caused by parasitic infestations
- Effectively eliminates both adult parasites and their eggs, reducing risk of recurrence
- Requires only one application for scabies in most cases, enhancing treatment adherence
- Suitable for use in patients as young as two months old under medical supervision
- Non-greasy formulation that absorbs well without staining clothing
- Available by prescription only, ensuring proper diagnosis and treatment guidance
Common use
Acticin cream is primarily indicated for the treatment of scabies infestations, a condition characterized by intense pruritus, papular eruptions, and characteristic burrow lines, particularly in interdigital spaces, wrists, and waistline areas. It is also prescribed for head lice infestations, targeting both live lice and nits attached to hair shafts. The medication may be used prophylactically for household members and close contacts of diagnosed cases to prevent transmission. Off-label uses may include treatment of other ectoparasitic infections such as body lice or pubic lice, though such applications require specific medical consultation.
Dosage and direction
For scabies treatment: Thoroughly massage Acticin cream into the skin from the chin down to the soles of the feet, paying particular attention to creases, folds, and under fingernails. A typical adult requires approximately 30g for complete coverage. Leave on for 8-14 hours before washing off thoroughly with soap and water. Most cases require only one application.
For head lice treatment: Apply sufficient cream to saturate hair and scalp. Leave on for 10 minutes before rinsing thoroughly with water and using a fine-toothed comb to remove dead lice and nits.
Reapplication is generally not recommended within two weeks unless live mites are observed. For infants and elderly patients, application may include the scalp and face (avoiding eyes and mouth), following specific pediatrician or geriatrician guidance.
Precautions
- For external use only; avoid contact with eyes, mucous membranes, and inside the nose or mouth
- Do not apply to acutely inflamed or broken skin unless directed by a physician
- May cause temporary burning, stinging, or tingling sensations upon application
- Use with caution in patients with known sensitivity to chrysanthemums or ragweed
- Clothing and bedding should be washed in hot water and dried on high heat after treatment
- Sexual partners and household members should be evaluated and potentially treated simultaneously
- Pruritus may persist for 2-4 weeks post-treatment due to residual mite antigens; this does not indicate treatment failure
Contraindications
Acticin is contraindicated in patients with known hypersensitivity to permethrin, any other pyrethroid, or pyrethrin. It should not be used in patients with history of severe allergic reactions to topical medications. The cream formulation is contraindicated for ophthalmic use or application to mucosal surfaces. Use during pregnancy should be avoided unless clearly needed and prescribed by a physician who has determined that benefits outweigh potential risks. Nursing mothers should consult healthcare providers before use.
Possible side effects
Most side effects are mild and transient, including:
- Temporary itching, burning, or stinging at application site (most common)
- Mild erythema, edema, or rash
- Numbness or tingling sensations
- Scalp discomfort with lice treatment
Less common reactions may include:
- Contact dermatitis or skin hypersensitivity
- Mild headache or dizziness
- Increased pruritus during the first week of treatment
Rare but serious side effects requiring immediate medical attention include:
- Severe skin reactions (blistering, peeling, severe redness)
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Intense skin pain
Drug interaction
No significant pharmacokinetic drug interactions have been documented with topical permethrin application due to minimal systemic absorption. However, patients using other topical medications (especially corticosteroids, retinoids, or abrasive agents) on the same treatment areas should consult their physician regarding application timing. Concurrent use with other pediculicides may increase risk of skin irritation and is generally not recommended. Patients taking medications that lower seizure threshold should use with caution under medical supervision.
Missed dose
As Acticin is typically administered as a single application for scabies treatment, the concept of “missed dose” does not generally apply. If the application was partially washed off prematurely or inadequately applied, consult a healthcare provider regarding potential reapplication. For head lice treatment, if the cream is rinsed off before the recommended 10 minutes, reapply immediately and maintain for the full duration. Do not apply additional treatment without medical consultation.
Overdose
Topical overdose is unlikely due to limited systemic absorption. Excessive application may lead to intensified local reactions including severe erythema, burning, or paresthesia. Accidental ingestion may cause pyrethroid toxicity symptoms including nausea, vomiting, abdominal pain, headache, dizziness, and in severe cases, seizures or respiratory difficulty. In case of ingestion, seek immediate medical attention and provide supportive care. Gastric lavage may be considered if presentation is early. There is no specific antidote for permethrin overdose.
Storage
Store at controlled room temperature (20-25°C or 68-77°F). Keep tube tightly closed when not in use. Do not freeze. Keep out of direct sunlight and away from excessive heat. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Properly discard any unused medication after treatment completion.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Acticin is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual results may vary. Always follow the specific instructions provided by your prescribing physician and read the medication guide included with your prescription. Do not use this medication for conditions other than those for which it was prescribed. Report any adverse reactions to your healthcare provider promptly.
Reviews
Clinical studies demonstrate Acticin’s efficacy with cure rates exceeding 95% for scabies when used appropriately. In a randomized controlled trial involving 467 patients, permethrin 5% cream showed significantly higher eradication rates compared to crotamiton and lindane preparations. Dermatologists frequently report high patient satisfaction due to the single-application protocol and rapid symptom relief. Some patients note persistent itching during the first week post-treatment, which is typically managed with antihistamines or topical corticosteroids. Pediatric applications show similar efficacy profiles with appropriate weight-based dosing considerations.